Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity

Huntington's disease (HD) is caused by a polyglutamine expansion within the huntingtin (Htt) protein. Both loss of function of normal Htt and gain of a toxic function by the polyglutamine-expanded mutant Htt protein have been proposed to be responsible for HD, although the molecular mechanisms...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of neuroscience 2013-07, Vol.33 (29), p.11833-11838
Hauptverfasser:	Bardai, Farah H, Verma, Pragya, Smith, Chad, Rawat, Varun, Wang, Lulu, D'Mello, Santosh R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Brief Communications Corpus Striatum - metabolism Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Histone Deacetylases - genetics Histone Deacetylases - metabolism Huntington Disease - metabolism Mice Mutation Neurons - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!