High-Yield Soluble Expression and Simple Purification of the Antimicrobial Peptide OG2 Using the Intein System in Escherichia coli

OG2 is a modified antimicrobial peptide, that is, derived from the frog peptide Palustrin-OG1. It has high antimicrobial activity and low cytotoxicity, and it is therefore promising as a therapeutic agent. Both prokaryotic (Escherichia coli) and eukaryotic (Pichia pastoris) production host systems w...

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Veröffentlicht in:	BioMed research international 2013-01, Vol.2013 (2013), p.1-6
Hauptverfasser:	Wang, Yi-Zhen, Choi, Young-Jun, Feng, Jie, Zhang, Hai-Wen, Luan, Chao, Han, Fei-Fei, Xie, Yong-Gang, Groleau, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Anti-Infective Agents Antimicrobial agents Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - isolation & purification Anura Biomedical research Chromatography Cloning Cloning, Molecular Cytotoxicity E coli Enzymes Escherichia coli - genetics Feed science Genetic Vectors Humans Inteins - genetics Microbiology Peptides Pichia - genetics Plasmids Proteins R&D Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Research & development
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