Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes

The juvenile hormones (JHs) play a central role in insect reproduction, development and behavior. Interrupting JH biosynthesis has long been considered a promising strategy for the development of target-specific insecticides. Using a combination of RNAi, in vivo and in vitro studies we characterized...

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Veröffentlicht in:	Insect biochemistry and molecular biology 2013-08, Vol.43 (8), p.675-682
Hauptverfasser:	Rivera-Perez, Crisalejandra, Nouzova, Marcela, Clifton, Mark. E., Garcia, Elena Martin, LeBlanc, Elizabeth, Noriega, Fernando G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - enzymology Aedes aegypti Age Factors aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Aldehyde dehydrogenase 3 Aldehyde Oxidoreductases - metabolism Aldo-keto reductase Animals biosynthesis catalytic activity Corpora allata Corpora Allata - enzymology Culicidae Farnesal farnesol Farnesol - analogs & derivatives Farnesol - metabolism Fatty Acids, Unsaturated - metabolism Female females Homeostasis humans in vitro studies insect reproduction insecticides Juvenile hormone juvenile hormones Juvenile Hormones - biosynthesis Mosquito RNA interference RNA, Messenger - metabolism RNAi sugars toxicity
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