Developmental exposure to polychlorinated biphenyls reduces amphetamine behavioral sensitization in Long–Evans rats

Abstract PCBs have long been known to affect dopamine (DA) function in the brain. The current study used an amphetamine behavioral sensitization paradigm in rats developmentally exposed to PCBs. Long–Evans rats were given perinatal exposure to 0, 3, or 6 mg/kg/day PCBs and behavioral sensitization t...

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Veröffentlicht in:	Neurotoxicology and teratology 2013-07, Vol.38, p.6-12
Hauptverfasser:	Poon, Emily, Monaikul, Supida, Kostyniak, Paul J, Chi, Lai Har, Schantz, Susan L, Sable, Helen J.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amphetamine Animals Behavioral pharmacology Behavioral sensitization Central Nervous System Sensitization - drug effects Dextroamphetamine - pharmacokinetics Dextroamphetamine - pharmacology Dose-Response Relationship, Drug Emergency Female Male Medical Education Motor Activity - drug effects Neurotoxicology Polychlorinated biphenyls Polychlorinated Biphenyls - administration & dosage Polychlorinated Biphenyls - toxicity Pregnancy Rats Rats, Long-Evans Time Factors
Online-Zugang:	Volltext
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