Structural determination of the phosphorylation domain of the ryanodine receptor

The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum membrane protein that is essential for Ca2+ cycling in both skeletal and cardiac muscle. Genetic mutations in RyR1 are associated with severe conditions including malignant hyperthermia (MH) and central core disease. One...

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Veröffentlicht in:	FEBS J 2012-10, Vol.279 (20), p.3952-3964
Hauptverfasser:	Sharma, Parveen, Ishiyama, Noboru, Nair, Usha, Li, Wenping, Dong, Aiping, Miyake, Tetsuaki, Wilson, Aaron, Ryan, Tim, MacLennan, David H., Kislinger, Thomas, Ikura, Mitsuhiko, Dhe‐Paganon, Sirano, Gramolini, Anthony O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - genetics Amino Acid Sequence Animals Binding Sites Blotting, Western Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cryoelectron Microscopy Crystal structure Crystallography, X-Ray excitation contraction HEK293 Cells Humans Kinases malignant hyperthermia Models, Molecular Molecular biology Molecular Sequence Data Mutation Phosphorylation phosphorylation site Protein Binding Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Structure, Secondary Protein Structure, Tertiary Proteins Rabbits Ryanodine Receptor Calcium Release Channel - chemistry Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism RyR Sequence Homology, Amino Acid X‐ray crystallography
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