Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
Much recent attention has been given to the carotid body because of its potential role in cardiovascular disease states. One disease, neurogenic hypertension, characterised by excessive sympathetic activity, appears dependent on carotid body activity that may or may not be accompanied by sleep-disor...
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| Veröffentlicht in: | Current hypertension reports 2013-08, Vol.15 (4), p.273-280 |
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| creator | Paton, Julian F. R. Ratcliffe, Laura Hering, Dagmara Wolf, Jacek Sobotka, Paul A. Narkiewicz, Krzysztof |
| description | Much recent attention has been given to the carotid body because of its potential role in cardiovascular disease states. One disease, neurogenic hypertension, characterised by excessive sympathetic activity, appears dependent on carotid body activity that may or may not be accompanied by sleep-disordered breathing. Herein, we review recent literature suggesting that the carotid body acquires tonicity in hypertension. We predict that carotid glomectomy will be a powerful way to temper excessive sympathetic discharge in diseases such as hypertension. We propose a model to explain that signalling from the ‘
hypertensive’
carotid body is tonic, and hypothesise that there will be a sub-population of glomus cells that channel separately into reflex pathways controlling sympathetic motor outflows. |
| doi_str_mv | 10.1007/s11906-013-0366-z |
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hypertensive’
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hypertensive’
carotid body is tonic, and hypothesise that there will be a sub-population of glomus cells that channel separately into reflex pathways controlling sympathetic motor outflows.</description><subject>Animals</subject><subject>Cardiology</subject><subject>Carotid Body - metabolism</subject><subject>Carotid Body - pathology</subject><subject>Carotid Body - physiopathology</subject><subject>Chemoreceptor Cells - metabolism</subject><subject>Family Medicine</subject><subject>General Practice</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension and the Heart (PW de Leeuw and AH Gradman</subject><subject>Hypertension and the Heart (PW de Leeuw and AH Gradman, Section Editors)</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nephrology</subject><subject>Primary Care Medicine</subject><subject>Reflex - physiology</subject><subject>Section Editors</subject><subject>Sleep Apnea Syndromes - etiology</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>1522-6417</issn><issn>1534-3111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kVFrFDEUhYMotlZ_gC8S8MWX0dxkJpl9EepirVBQlvocMsmd3ZTZZE0yhe2vN-vWUgWfbuB859xcDiGvgb0HxtSHDLBgsmEgGiakbO6ekFPoRNsIAHh6eHPeyBbUCXmR8w1jvLrUc3LCRc97aNUp0Su8xckUH0Om50OcC12aFIt39FN0e3oxB3sQ6fUmxXm9ob5k-t2UTZzi2lsz0VWckPpAV5h9LiYUernfYSoYcvW9JM9GM2V8dT_PyI-Lz9fLy-bq25evy_OrxnZClmZkbBilQOcMdpY5Zt246EFxZVSP0PJx7J2Qhg_CcDf0zlRtofiIqKzsnDgjH4-5u3nYorMYSjKT3iW_NWmvo_H6byX4jV7HWy0UcBBtDXh3H5Dizxlz0VufLU6TCRjnrKFlTHKhRFfRt_-gN3FOoZ73m2K9FC2vFBwpm2LOCceHzwDTh_r0sT5d69OH-vRd9bx5fMWD409fFeBHIFcprDE9Wv3f1F_8Qqhj</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Paton, Julian F. 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hypertensive’
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| subjects | Animals Cardiology Carotid Body - metabolism Carotid Body - pathology Carotid Body - physiopathology Chemoreceptor Cells - metabolism Family Medicine General Practice Humans Hypertension Hypertension - complications Hypertension - metabolism Hypertension - physiopathology Hypertension and the Heart (PW de Leeuw and AH Gradman Hypertension and the Heart (PW de Leeuw and AH Gradman, Section Editors) Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Nephrology Primary Care Medicine Reflex - physiology Section Editors Sleep Apnea Syndromes - etiology Sleep Apnea Syndromes - physiopathology Sympathetic Nervous System - physiopathology |
| title | Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension |
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