CD8+ Effector T Cells at the Fetal-Maternal Interface, Balancing Fetal Tolerance and Antiviral Immunity

During pregnancy CD8+ effector T cells need optimal immune regulation to prevent a detrimental response to allogeneic fetal cells while providing immune protection to infections. A significant proportion of (prospective) mothers carry naïve or memory CD8+ T cells with a TCR that can directly bind to...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 2013-04, Vol.69 (4), p.395-407
Hauptverfasser:	Tilburgs, Tamara, Strominger, Jack L.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8+ T cells CD8-Positive T-Lymphocytes - immunology effector memory Female fetal-maternal tolerance Fetus - immunology Histocompatibility, Maternal-Fetal HLA Antigens - immunology HLA-C Humans Immune Tolerance Inflammation - immunology Lymphocyte Activation mHag Placenta - immunology Pregnancy Pregnancy Complications - immunology Receptors, Antigen, T-Cell - immunology T-Lymphocyte Subsets - immunology Trophoblasts - immunology virus Viruses - immunology
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