Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy

Objectives We assessed the impact of tocilizumab (TCZ), a humanised monoclonal anti-interleukin-6 receptor antibody, on antibody response following administration of the 23-valent pneumococcal polysaccharide vaccine (PPV23). Methods A total of 190 patients with rheumatoid arthritis (RA) received PPV...

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Veröffentlicht in:	Annals of the rheumatic diseases 2013-08, Vol.72 (8), p.1362-1366
Hauptverfasser:	Mori, Shunsuke, Ueki, Yukitaka, Akeda, Yukihiro, Hirakata, Naoyuki, Oribe, Motohiro, Shiohira, Yoshiki, Hidaka, Toshihiko, Oishi, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Humanized - therapeutic use Antibody Formation - drug effects Antigens Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Clinical and Epidemiological Research Disease Drug dosages Drug Therapy, Combination Female Humans Immunoglobulin G - blood Infections Male Methotrexate Methotrexate - therapeutic use Mortality Opsonin Proteins - immunology Patients Phagocytosis - immunology Pneumococcal Vaccines - immunology Pneumonia Polysaccharides, Bacterial - blood Polysaccharides, Bacterial - immunology Rheumatoid Arthritis Rheumatology Serotyping Statistical analysis Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Vaccination Vaccines
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