Functional Modulation of the Glutamate Transporter Variant GLT1b by the PDZ Domain Protein PICK1

The dominant glutamate transporter isoform in the mammalian brain, GLT1, exists as at least three splice variants, GLT1a, GLT1b, and GLT1c. GLT1b interacts with the scaffold protein PICK1 (protein interacting with kinase C1), which is implicated in glutamatergic neurotransmission via its regulatory...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2013-07, Vol.288 (28), p.20195-20207
Hauptverfasser:	Sogaard, Rikke, Borre, Lars, Braunstein, Thomas H., Madsen, Kenneth L., MacAulay, Nanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Animals BAR Domain Blotting, Western Carrier Proteins - genetics Carrier Proteins - metabolism Cytoskeletal Proteins Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Female Glutamate Glutamic Acid - metabolism Glutamic Acid - pharmacology Leak Current Membrane Potentials - drug effects Membrane Potentials - physiology Microscopy, Fluorescence Neurobiology Neurotransmitter Transport Nuclear Proteins - genetics Nuclear Proteins - metabolism Oocytes - metabolism Oocytes - physiology PDZ Domain PICK1 Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein Kinase C (PKC) Protein Kinase C - metabolism Protein-Protein Interactions Rats Tritium Xenopus laevis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!