IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibod...
Gespeichert in:
| Veröffentlicht in: | Journal of investigative dermatology 2012-11, Vol.132 (11), p.2573-2580 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2580 |
|---|---|
| container_issue | 11 |
| container_start_page | 2573 |
| container_title | Journal of investigative dermatology |
| container_volume | 132 |
| creator | Flores, Gustavo Culton, Donna A. Prisayanh, Phillip Qaqish, Bahjat F. James, Kirk Maldonado, Mike Aoki, Valeria Hans-Filho, Gunter Rivitti, Evandro A. Diaz, Luis A. |
| description | It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls. |
| doi_str_mv | 10.1038/jid.2012.232 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3710730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022202X15355184</els_id><sourcerecordid>2789466681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-a027b110a15bc1cf82e1aff221e9cd4dbd491c64d6a7d3a6fbd2c0625b2e39543</originalsourceid><addsrcrecordid>eNqF0dtrFDEUB-BBFLtW33yWAREqOGvOydz2RShLtxYLihfwLWSSM7NZZpI1mVnY_960u60XBJ8Ski-Hc_JLkufA5sB4_XZj9BwZ4Bw5PkhmUCDPoMqrh8mMMcQMGX4_SZ6EsGEMyryoHycniHV8y-pZ0l11l-n5NDppR9M4vU8_U9g6GyiVnTQ2jOkH8nI01qn9SOlS6jX5eJ4am15YTYNR6ScatmvTTSFdud5IRXF3tnKdS79Qv5MdDa-fJo9a2Qd6dlxPk2-ri6_L99n1x8ur5fl1pgrEMZMMqwaASSgaBaqtkUC2LSLQQulcNzpfgCpzXcpKc1m2jUbFSiwaJL4ocn6avDvU3U7NQFqRHb3sxdabQfq9cNKIP2-sWYvO7QSvgFWcxQJnxwLe_ZgojGIwQVHfS0tuCgJiL5BzhvB_CoBlVTNeRvryL7pxk7fxJ24VVAsOVVRvDkp5F4Kn9r5vYOImbBHDFjdhixh25C9-n_Ue36UbwasjkEHJvvXSKhN-ubJgZY1FdOXBUUxmZ8iLoAxZRdp4UqPQzvy7g5_yfcTl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1112179317</pqid></control><display><type>article</type><title>IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Flores, Gustavo ; Culton, Donna A. ; Prisayanh, Phillip ; Qaqish, Bahjat F. ; James, Kirk ; Maldonado, Mike ; Aoki, Valeria ; Hans-Filho, Gunter ; Rivitti, Evandro A. ; Diaz, Luis A.</creator><creatorcontrib>Flores, Gustavo ; Culton, Donna A. ; Prisayanh, Phillip ; Qaqish, Bahjat F. ; James, Kirk ; Maldonado, Mike ; Aoki, Valeria ; Hans-Filho, Gunter ; Rivitti, Evandro A. ; Diaz, Luis A. ; for the Cooperative Group on Fogo Selvagem Research</creatorcontrib><description>It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.2012.232</identifier><identifier>PMID: 22810308</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Autoantibodies ; Autoantibodies - immunology ; Biological and medical sciences ; Brazil ; Bullous diseases of the skin ; Cadherin ; Cadherins - genetics ; Cadherins - immunology ; Cross Reactions - immunology ; Dermatology ; desmoglein 1 ; Desmoglein 1 - genetics ; Desmoglein 1 - immunology ; Desmoglein 2 - genetics ; Desmoglein 2 - immunology ; desmoglein 3 ; Desmoglein 3 - genetics ; Desmoglein 3 - immunology ; Desmogleins - genetics ; Desmogleins - immunology ; Desmosomal Cadherins - genetics ; Desmosomal Cadherins - immunology ; E-Cadherin ; Enzyme-linked immunosorbent assay ; Humans ; Immunoglobulin G ; Immunoglobulin G - immunology ; Keratinocytes ; Keratinocytes - immunology ; Medical sciences ; Pemphigus - immunology ; Pemphigus foliaceus ; pemphigus vulgaris ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; ROC Curve ; United States</subject><ispartof>Journal of investigative dermatology, 2012-11, Vol.132 (11), p.2573-2580</ispartof><rights>2012 The Society for Investigative Dermatology, Inc</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-a027b110a15bc1cf82e1aff221e9cd4dbd491c64d6a7d3a6fbd2c0625b2e39543</citedby><cites>FETCH-LOGICAL-c522t-a027b110a15bc1cf82e1aff221e9cd4dbd491c64d6a7d3a6fbd2c0625b2e39543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1112179317?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26506825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22810308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flores, Gustavo</creatorcontrib><creatorcontrib>Culton, Donna A.</creatorcontrib><creatorcontrib>Prisayanh, Phillip</creatorcontrib><creatorcontrib>Qaqish, Bahjat F.</creatorcontrib><creatorcontrib>James, Kirk</creatorcontrib><creatorcontrib>Maldonado, Mike</creatorcontrib><creatorcontrib>Aoki, Valeria</creatorcontrib><creatorcontrib>Hans-Filho, Gunter</creatorcontrib><creatorcontrib>Rivitti, Evandro A.</creatorcontrib><creatorcontrib>Diaz, Luis A.</creatorcontrib><creatorcontrib>for the Cooperative Group on Fogo Selvagem Research</creatorcontrib><title>IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.</description><subject>Adult</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Bullous diseases of the skin</subject><subject>Cadherin</subject><subject>Cadherins - genetics</subject><subject>Cadherins - immunology</subject><subject>Cross Reactions - immunology</subject><subject>Dermatology</subject><subject>desmoglein 1</subject><subject>Desmoglein 1 - genetics</subject><subject>Desmoglein 1 - immunology</subject><subject>Desmoglein 2 - genetics</subject><subject>Desmoglein 2 - immunology</subject><subject>desmoglein 3</subject><subject>Desmoglein 3 - genetics</subject><subject>Desmoglein 3 - immunology</subject><subject>Desmogleins - genetics</subject><subject>Desmogleins - immunology</subject><subject>Desmosomal Cadherins - genetics</subject><subject>Desmosomal Cadherins - immunology</subject><subject>E-Cadherin</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - immunology</subject><subject>Keratinocytes</subject><subject>Keratinocytes - immunology</subject><subject>Medical sciences</subject><subject>Pemphigus - immunology</subject><subject>Pemphigus foliaceus</subject><subject>pemphigus vulgaris</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>ROC Curve</subject><subject>United States</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0dtrFDEUB-BBFLtW33yWAREqOGvOydz2RShLtxYLihfwLWSSM7NZZpI1mVnY_960u60XBJ8Ski-Hc_JLkufA5sB4_XZj9BwZ4Bw5PkhmUCDPoMqrh8mMMcQMGX4_SZ6EsGEMyryoHycniHV8y-pZ0l11l-n5NDppR9M4vU8_U9g6GyiVnTQ2jOkH8nI01qn9SOlS6jX5eJ4am15YTYNR6ScatmvTTSFdud5IRXF3tnKdS79Qv5MdDa-fJo9a2Qd6dlxPk2-ri6_L99n1x8ur5fl1pgrEMZMMqwaASSgaBaqtkUC2LSLQQulcNzpfgCpzXcpKc1m2jUbFSiwaJL4ocn6avDvU3U7NQFqRHb3sxdabQfq9cNKIP2-sWYvO7QSvgFWcxQJnxwLe_ZgojGIwQVHfS0tuCgJiL5BzhvB_CoBlVTNeRvryL7pxk7fxJ24VVAsOVVRvDkp5F4Kn9r5vYOImbBHDFjdhixh25C9-n_Ue36UbwasjkEHJvvXSKhN-ubJgZY1FdOXBUUxmZ8iLoAxZRdp4UqPQzvy7g5_yfcTl</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Flores, Gustavo</creator><creator>Culton, Donna A.</creator><creator>Prisayanh, Phillip</creator><creator>Qaqish, Bahjat F.</creator><creator>James, Kirk</creator><creator>Maldonado, Mike</creator><creator>Aoki, Valeria</creator><creator>Hans-Filho, Gunter</creator><creator>Rivitti, Evandro A.</creator><creator>Diaz, Luis A.</creator><general>Elsevier Inc</general><general>Nature Publishing Group</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121101</creationdate><title>IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)</title><author>Flores, Gustavo ; Culton, Donna A. ; Prisayanh, Phillip ; Qaqish, Bahjat F. ; James, Kirk ; Maldonado, Mike ; Aoki, Valeria ; Hans-Filho, Gunter ; Rivitti, Evandro A. ; Diaz, Luis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-a027b110a15bc1cf82e1aff221e9cd4dbd491c64d6a7d3a6fbd2c0625b2e39543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Bullous diseases of the skin</topic><topic>Cadherin</topic><topic>Cadherins - genetics</topic><topic>Cadherins - immunology</topic><topic>Cross Reactions - immunology</topic><topic>Dermatology</topic><topic>desmoglein 1</topic><topic>Desmoglein 1 - genetics</topic><topic>Desmoglein 1 - immunology</topic><topic>Desmoglein 2 - genetics</topic><topic>Desmoglein 2 - immunology</topic><topic>desmoglein 3</topic><topic>Desmoglein 3 - genetics</topic><topic>Desmoglein 3 - immunology</topic><topic>Desmogleins - genetics</topic><topic>Desmogleins - immunology</topic><topic>Desmosomal Cadherins - genetics</topic><topic>Desmosomal Cadherins - immunology</topic><topic>E-Cadherin</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - immunology</topic><topic>Keratinocytes</topic><topic>Keratinocytes - immunology</topic><topic>Medical sciences</topic><topic>Pemphigus - immunology</topic><topic>Pemphigus foliaceus</topic><topic>pemphigus vulgaris</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>ROC Curve</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flores, Gustavo</creatorcontrib><creatorcontrib>Culton, Donna A.</creatorcontrib><creatorcontrib>Prisayanh, Phillip</creatorcontrib><creatorcontrib>Qaqish, Bahjat F.</creatorcontrib><creatorcontrib>James, Kirk</creatorcontrib><creatorcontrib>Maldonado, Mike</creatorcontrib><creatorcontrib>Aoki, Valeria</creatorcontrib><creatorcontrib>Hans-Filho, Gunter</creatorcontrib><creatorcontrib>Rivitti, Evandro A.</creatorcontrib><creatorcontrib>Diaz, Luis A.</creatorcontrib><creatorcontrib>for the Cooperative Group on Fogo Selvagem Research</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flores, Gustavo</au><au>Culton, Donna A.</au><au>Prisayanh, Phillip</au><au>Qaqish, Bahjat F.</au><au>James, Kirk</au><au>Maldonado, Mike</au><au>Aoki, Valeria</au><au>Hans-Filho, Gunter</au><au>Rivitti, Evandro A.</au><au>Diaz, Luis A.</au><aucorp>for the Cooperative Group on Fogo Selvagem Research</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem)</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>132</volume><issue>11</issue><spage>2573</spage><epage>2580</epage><pages>2573-2580</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22810308</pmid><doi>10.1038/jid.2012.232</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 2012-11, Vol.132 (11), p.2573-2580 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3710730 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Adult Autoantibodies Autoantibodies - immunology Biological and medical sciences Brazil Bullous diseases of the skin Cadherin Cadherins - genetics Cadherins - immunology Cross Reactions - immunology Dermatology desmoglein 1 Desmoglein 1 - genetics Desmoglein 1 - immunology Desmoglein 2 - genetics Desmoglein 2 - immunology desmoglein 3 Desmoglein 3 - genetics Desmoglein 3 - immunology Desmogleins - genetics Desmogleins - immunology Desmosomal Cadherins - genetics Desmosomal Cadherins - immunology E-Cadherin Enzyme-linked immunosorbent assay Humans Immunoglobulin G Immunoglobulin G - immunology Keratinocytes Keratinocytes - immunology Medical sciences Pemphigus - immunology Pemphigus foliaceus pemphigus vulgaris Recombinant Proteins - genetics Recombinant Proteins - immunology ROC Curve United States |
| title | IgG Autoantibody Response against Keratinocyte Cadherins in Endemic Pemphigus Foliaceus (Fogo Selvagem) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T00%3A35%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IgG%20Autoantibody%20Response%20against%20Keratinocyte%20Cadherins%20in%20Endemic%20Pemphigus%20Foliaceus%20(Fogo%20Selvagem)&rft.jtitle=Journal%20of%20investigative%20dermatology&rft.au=Flores,%20Gustavo&rft.aucorp=for%20the%20Cooperative%20Group%20on%20Fogo%20Selvagem%20Research&rft.date=2012-11-01&rft.volume=132&rft.issue=11&rft.spage=2573&rft.epage=2580&rft.pages=2573-2580&rft.issn=0022-202X&rft.eissn=1523-1747&rft.coden=JIDEAE&rft_id=info:doi/10.1038/jid.2012.232&rft_dat=%3Cproquest_pubme%3E2789466681%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1112179317&rft_id=info:pmid/22810308&rft_els_id=S0022202X15355184&rfr_iscdi=true |