The RECQL4 protein, deficient in Rothmund–Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions

•RECQL4 preferentially unwinds telomeric substrates containing thymine glycol (Tg).•TRF2, a telomeric shelterin protein, stimulates RECQL4 helicase in presence of Tg.•RECQL4 binding is unchanged but TRF2 binds Tg-containing D-loops with less affinity.•WRN, but not RECQL4, stimulates NEIL1 glycosylas...

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Veröffentlicht in:	DNA repair 2013-07, Vol.12 (7), p.518-528
Hauptverfasser:	Ferrarelli, Leslie K., Popuri, Venkateswarlu, Ghosh, Avik K., Tadokoro, Takashi, Canugovi, Chandrika, Hsu, Joseph K., Croteau, Deborah L., Bohr, Vilhelm A.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - metabolism DNA Adducts - metabolism DNA Damage DNA Repair Exodeoxyribonucleases - metabolism Humans Nucleic Acid Conformation Oxidation-Reduction Reactive Oxygen Species - metabolism RecQ Helicases - metabolism RECQL4 Rothmund-Thomson Syndrome - genetics Rothmund-Thomson Syndrome - metabolism Telomere - chemistry Telomere - metabolism Telomeres Telomeric Repeat Binding Protein 2 - metabolism Thymine - analogs & derivatives Thymine - metabolism Thymine glycol Werner Syndrome Helicase WRN
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