Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex

Rationale Endocannabinoid, opioid, and dopamine systems interact to exhibit cannabinoid receptor neuromodulation of opioid peptides and D 4 dopamine receptor gene expression in CB 1 -cannabinoid-deficient mouse striatum. Objective Using CB 1 -transgenic mice, we examine primary age–sex influences an...

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Veröffentlicht in:	Psychopharmacology 2008-07, Vol.198 (4), p.497-508
Hauptverfasser:	Gerald, Tonya M., Howlett, Allyn C., Ward, Gregg R., Ho, Cheryl, Franklin, Steven O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biomedical and Life Sciences Biomedicine Female Gene expression Gene Expression - physiology Male Mice Mice, Knockout Neostriatum - metabolism Neurosciences Opioid Peptides - genetics Original Investigation Pharmacology Pharmacology/Toxicology Psychiatry Psychology Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - physiology Receptors, Dopamine - genetics Receptors, Dopamine D1 - genetics Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 - genetics Receptors, Dopamine D4 - genetics Receptors, Dopamine D5 - genetics Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Receptors, Opioid - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Sex Characteristics Transgenic animals
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