Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

The NLRP3 inflammasome is primarily known for producing inflammatory cytokines and inducing pyroptosis. Stuart and colleagues identify an additional role for NLRP3 in driving down the pH of phagosomes. Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates micr...

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Veröffentlicht in:	Nature immunology 2013-06, Vol.14 (6), p.543-553
Hauptverfasser:	Sokolovska, Anna, Becker, Christine E, Ip, W K Eddie, Rathinam, Vijay A K, Brudner, Matthew, Paquette, Nicholas, Tanne, Antoine, Vanaja, Sivapriya K, Moore, Kathryn J, Fitzgerald, Katherine A, Lacy-Hulbert, Adam, Stuart, Lynda M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 Acidification Animals Bacteria Biomedicine Carrier Proteins - immunology Carrier Proteins - metabolism Caspase 1 - immunology Caspase 1 - metabolism Cells, Cultured Enzyme Activation - immunology Flow Cytometry Genetic aspects Health aspects HEK293 Cells Host-Pathogen Interactions - immunology Humans Hydrogen-Ion Concentration Immunoblotting Immunology Infectious Diseases Inflammasomes - immunology Inflammasomes - metabolism Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Confocal Microscopy, Electron NADPH Oxidase 2 NADPH Oxidases - immunology NADPH Oxidases - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Oxidases Phagocytosis - immunology Phagosomes Phagosomes - immunology Phagosomes - metabolism Phagosomes - microbiology Phagosomes - ultrastructure Physiological aspects Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Staphylococcus aureus - immunology Staphylococcus aureus - physiology
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