Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer

Background: Non-muscle invasive (NMI) bladder cancer is characterised by increased expression and activating mutations of FGFR3. We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100. In this study, we investigated the effects of hyp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2013-07, Vol.109 (1), p.50-59
Hauptverfasser:	Blick, C, Ramachandran, A, Wigfield, S, McCormick, R, Jubb, A, Buffa, F M, Turley, H, Knowles, M A, Cranston, D, Catto, J, Harris, A L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/67/589/1336 631/80/86 Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Hypoxia - genetics Cell Line, Tumor Cell Proliferation Cell Survival Clinical Study Drug Resistance Epidemiology Gene Expression Gene Expression Regulation, Neoplastic Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Medical sciences MicroRNAs - metabolism Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness Nephrology. Urinary tract diseases Oncology Receptor, Fibroblast Growth Factor, Type 3 - biosynthesis Receptor, Fibroblast Growth Factor, Type 3 - genetics Receptor, Fibroblast Growth Factor, Type 3 - metabolism RNA Interference RNA, Small Interfering Transcription, Genetic Tumors Tumors of the urinary system Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!