Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1

Ataxia telangiectasia and Rad3-related (ATR) is a phosphoinositol-3-kinase like kinase (PIKK) that initiates a signal transduction response to replication fork stalling. Defects in ATR signalling have been reported in several disorders characterized by microcephaly and growth delay. Here, we gain in...

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Veröffentlicht in:	Human molecular genetics 2008-10, Vol.17 (20), p.3247-3253
Hauptverfasser:	Stiff, Tom, Cerosaletti, Karen, Concannon, Patrick, O'Driscoll, Mark, Jeggo, Penny A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia - genetics Ataxia Telangiectasia - metabolism Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Division Cell Line DNA Damage DNA Repair DNA Replication Fundamental and applied biological sciences. Psychology G2 Phase Genetics of eukaryotes. Biological and molecular evolution Histones - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Molecular and cellular biology Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Trans-Activators - metabolism Tumor Suppressor p53-Binding Protein 1 Ultraviolet Rays
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