Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity
Females develop less age-dependent loss of renal function, which may be in part due to cardiorenal protective effects of estrogens. The impact of androgen level on cardiovascular-renal health is controversial. Estrogen acts through multiple mechanisms, sometimes beneficial, sometimes damaging, which...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2012-12, Vol.67 (12), p.1365-1372 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Baylis, Chris |
| description | Females develop less age-dependent loss of renal function, which may be in part due to cardiorenal protective effects of estrogens. The impact of androgen level on cardiovascular-renal health is controversial. Estrogen acts through multiple mechanisms, sometimes beneficial, sometimes damaging, which makes it difficult to predict the effect of hormone replacement therapy (HRT) in an aging population. Nitric oxide (NO) deficiency occurs in aging and contributes to age-dependent cardiovascular risk and kidney damage. The increased oxidative stress of aging has effects at multiple sites in the NO biosynthetic pathway to lower NO production/action. Loss of NO together with activated angiotensin promotes some of the decrements in cardiovascular-renal function seen with age, which may be related to actions of the sex steroids. |
| doi_str_mv | 10.1093/gerona/gls171 |
| format | Article |
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The impact of androgen level on cardiovascular-renal health is controversial. Estrogen acts through multiple mechanisms, sometimes beneficial, sometimes damaging, which makes it difficult to predict the effect of hormone replacement therapy (HRT) in an aging population. Nitric oxide (NO) deficiency occurs in aging and contributes to age-dependent cardiovascular risk and kidney damage. The increased oxidative stress of aging has effects at multiple sites in the NO biosynthetic pathway to lower NO production/action. Loss of NO together with activated angiotensin promotes some of the decrements in cardiovascular-renal function seen with age, which may be related to actions of the sex steroids.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/gls171</identifier><identifier>PMID: 22960474</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>ACE inhibitors ; Aged ; Aging - physiology ; Androgens - physiology ; Angiotensin II - physiology ; Animals ; Cardiovascular disease ; Estrogens ; Female ; Glomerular Filtration Rate - physiology ; Humans ; Kidney diseases ; Kidney Glomerulus - physiology ; Male ; Nitric oxide ; Nitric Oxide - deficiency ; Oxidative Stress - physiology ; Review ; Sex Characteristics ; Womens health</subject><ispartof>The journals of gerontology. 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Loss of NO together with activated angiotensin promotes some of the decrements in cardiovascular-renal function seen with age, which may be related to actions of the sex steroids.</description><subject>ACE inhibitors</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Androgens - physiology</subject><subject>Angiotensin II - physiology</subject><subject>Animals</subject><subject>Cardiovascular disease</subject><subject>Estrogens</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Glomerulus - physiology</subject><subject>Male</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - deficiency</subject><subject>Oxidative Stress - physiology</subject><subject>Review</subject><subject>Sex Characteristics</subject><subject>Womens health</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2LFDEQxYMo7jp69CoBLx5sNx-dj_YgyOKuAwseVPAW0unqnqzdyZh0Nzv_vRlmXdSCVCXkx-MVD6GXlLyjpOEXA6QY7MUwZqroI3ROldCV4OLH43InqqkEIfIMPcv5lhxLsKfojLFGklrV52j8CneLHXHnp5j2O5-n93jeAbaDDwP-6bsAh7fYhzWOK0wQZhx7HPycvMPxzneAO-i98xBc4Wzoyhl8nCFkH_B2i-MKybrZr34-PEdPejtmeHE_N-j71advl5-rmy_X28uPN5WrNZ0roS0jjWpB1ETqFmh5Sqas7qEhzlrd9g0IzWnjetdJzRXjAqxkNWOU1y3foA8n3f3STtC5YjvZ0eyTn2w6mGi9-fcn-J0Z4mq4IlpQUQTe3Auk-GuBPJvJZwfjaAPEJRtKlZaNYFIW9PV_6G1cUijrHSnOa3bsG1SdKJdizgn6BzOUmGOO5pSjOeVY-Fd_b_BA_wmO_waftp0K</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Baylis, Chris</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121201</creationdate><title>Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity</title><author>Baylis, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-58a2097be54068be1a20627a8fe90caa8bf9e58319cfcd6837235ea62422134b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ACE inhibitors</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Androgens - physiology</topic><topic>Angiotensin II - physiology</topic><topic>Animals</topic><topic>Cardiovascular disease</topic><topic>Estrogens</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Glomerulus - physiology</topic><topic>Male</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - deficiency</topic><topic>Oxidative Stress - physiology</topic><topic>Review</topic><topic>Sex Characteristics</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baylis, Chris</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. 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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2012-12, Vol.67 (12), p.1365-1372 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | MEDLINE; Oxford Journals Online; Alma/SFX Local Collection |
| subjects | ACE inhibitors Aged Aging - physiology Androgens - physiology Angiotensin II - physiology Animals Cardiovascular disease Estrogens Female Glomerular Filtration Rate - physiology Humans Kidney diseases Kidney Glomerulus - physiology Male Nitric oxide Nitric Oxide - deficiency Oxidative Stress - physiology Review Sex Characteristics Womens health |
| title | Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity |
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