Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis
The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-init...
Gespeichert in:
| Veröffentlicht in: | International journal of biomedical science 2013-06, Vol.9 (2), p.68-74 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 74 |
|---|---|
| container_issue | 2 |
| container_start_page | 68 |
| container_title | International journal of biomedical science |
| container_volume | 9 |
| creator | Rajendran, Peramaiyan Jayakumar, Thangavel Nishigaki, Ikuo Ekambaram, Ganapathy Nishigaki, Yutaka Vetriselvi, Jayabal Sakthisekaran, Dhanapal |
| description | The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p |
| doi_str_mv | 10.59566/IJBS.2013.9068 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3708270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>23847456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-b9842a41eb49ee7163f64805662ff3908a8f85fb76bcb226524b85704178a90e3</originalsourceid><addsrcrecordid>eNpVkM1LAzEQxYMotlbP3iRHPWybZDcfexHaUrVSUVDPIbubtJFuUvZDrX-9aatFYWAGZt6bxw-Ac4z6NKWMDab3o-c-QTjup4iJA9DFlNKICIwOtzOKUo5IB5zU9RtClBFMjkGHxCLhCWVdUE7LsnW-9EW7VI2v1nBijM4b6A18UG5uja6sg6Emn6swlto1agmHzpZqWcMP2yzgSLsvf6muntaVdjqyrmhzXcBZ6-ZwrKrcOj8Pi9rWp-DIBJk---k98HozeRnfRbPH2-l4OItywngTZalIiEqwzpJUa45ZbFgiQnpGjIlTJJQwgpqMsyzPCGGUJJmgHCWYC5UiHffA9c531WalLvIQulJLuQr5VbWWXln5f-PsQs79u4w5EoSjYDDYGeSVr-tKm70WI7klLzfk5Ya83JAPiou_L_f3v6jjb_zDgVo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Rajendran, Peramaiyan ; Jayakumar, Thangavel ; Nishigaki, Ikuo ; Ekambaram, Ganapathy ; Nishigaki, Yutaka ; Vetriselvi, Jayabal ; Sakthisekaran, Dhanapal</creator><creatorcontrib>Rajendran, Peramaiyan ; Jayakumar, Thangavel ; Nishigaki, Ikuo ; Ekambaram, Ganapathy ; Nishigaki, Yutaka ; Vetriselvi, Jayabal ; Sakthisekaran, Dhanapal ; NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan ; Department of Pharmacology and Environmental Toxicology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India ; Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India ; Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi, Thanjavur, India</creatorcontrib><description><![CDATA[The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p<0.001), as well as NBT reduction, were decreased in the B(a)P-treated animals;whereas increased levels of immunocompetence were noted in the mangiferin-treated animals given B(a)P (p<0.001, p<0.05). The levels of immunoglobulins such as IgG and IgM were decreased considerably (p<0.001) in the B(a)P-treated animals compared with their levels in the control animals; whereas the IgA level was increased (p<0.001). In the mangiferin-treated experimental animals given B(a)P, the levels of IgG and IgM were significantly (p<0.001, p<0.05) increased whereas the IgA level was decreased compared with those for the B(a)P-treated mice. Oxidative changes in lymphocytes, neutrophils, and macrophages were also measured. The enhanced lipid peroxidation and decreased catalase and superoxide dismutase activities found in the lymphocytes, polymorphonuclear cells (PMN), and macrophages from B(a)P-treated mice were significantly reduced and increased, respectively, by the mangiferin treatment. This study confirms the immunomodulatory effect of mangiferin and shows an immunoprotective role arbitrated through a reduction in the reactive intermediate-induced oxidative stress in lymphocytes, neutrophils, and macrophages.]]></description><identifier>ISSN: 1550-9702</identifier><identifier>EISSN: 1555-2810</identifier><identifier>DOI: 10.59566/IJBS.2013.9068</identifier><identifier>PMID: 23847456</identifier><language>eng</language><publisher>United States: Master Publishing Group</publisher><subject>Original</subject><ispartof>International journal of biomedical science, 2013-06, Vol.9 (2), p.68-74</ispartof><rights>Peramaiyan Rajendran . Licensee Master Publishing Group 2013 Peramaiyan Rajendran</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-b9842a41eb49ee7163f64805662ff3908a8f85fb76bcb226524b85704178a90e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23847456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajendran, Peramaiyan</creatorcontrib><creatorcontrib>Jayakumar, Thangavel</creatorcontrib><creatorcontrib>Nishigaki, Ikuo</creatorcontrib><creatorcontrib>Ekambaram, Ganapathy</creatorcontrib><creatorcontrib>Nishigaki, Yutaka</creatorcontrib><creatorcontrib>Vetriselvi, Jayabal</creatorcontrib><creatorcontrib>Sakthisekaran, Dhanapal</creatorcontrib><creatorcontrib>NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan</creatorcontrib><creatorcontrib>Department of Pharmacology and Environmental Toxicology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</creatorcontrib><creatorcontrib>Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</creatorcontrib><creatorcontrib>Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi, Thanjavur, India</creatorcontrib><title>Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis</title><title>International journal of biomedical science</title><addtitle>Int J Biomed Sci</addtitle><description><![CDATA[The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p<0.001), as well as NBT reduction, were decreased in the B(a)P-treated animals;whereas increased levels of immunocompetence were noted in the mangiferin-treated animals given B(a)P (p<0.001, p<0.05). The levels of immunoglobulins such as IgG and IgM were decreased considerably (p<0.001) in the B(a)P-treated animals compared with their levels in the control animals; whereas the IgA level was increased (p<0.001). In the mangiferin-treated experimental animals given B(a)P, the levels of IgG and IgM were significantly (p<0.001, p<0.05) increased whereas the IgA level was decreased compared with those for the B(a)P-treated mice. Oxidative changes in lymphocytes, neutrophils, and macrophages were also measured. The enhanced lipid peroxidation and decreased catalase and superoxide dismutase activities found in the lymphocytes, polymorphonuclear cells (PMN), and macrophages from B(a)P-treated mice were significantly reduced and increased, respectively, by the mangiferin treatment. This study confirms the immunomodulatory effect of mangiferin and shows an immunoprotective role arbitrated through a reduction in the reactive intermediate-induced oxidative stress in lymphocytes, neutrophils, and macrophages.]]></description><subject>Original</subject><issn>1550-9702</issn><issn>1555-2810</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpVkM1LAzEQxYMotlbP3iRHPWybZDcfexHaUrVSUVDPIbubtJFuUvZDrX-9aatFYWAGZt6bxw-Ac4z6NKWMDab3o-c-QTjup4iJA9DFlNKICIwOtzOKUo5IB5zU9RtClBFMjkGHxCLhCWVdUE7LsnW-9EW7VI2v1nBijM4b6A18UG5uja6sg6Emn6swlto1agmHzpZqWcMP2yzgSLsvf6muntaVdjqyrmhzXcBZ6-ZwrKrcOj8Pi9rWp-DIBJk---k98HozeRnfRbPH2-l4OItywngTZalIiEqwzpJUa45ZbFgiQnpGjIlTJJQwgpqMsyzPCGGUJJmgHCWYC5UiHffA9c531WalLvIQulJLuQr5VbWWXln5f-PsQs79u4w5EoSjYDDYGeSVr-tKm70WI7klLzfk5Ya83JAPiou_L_f3v6jjb_zDgVo</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Rajendran, Peramaiyan</creator><creator>Jayakumar, Thangavel</creator><creator>Nishigaki, Ikuo</creator><creator>Ekambaram, Ganapathy</creator><creator>Nishigaki, Yutaka</creator><creator>Vetriselvi, Jayabal</creator><creator>Sakthisekaran, Dhanapal</creator><general>Master Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201306</creationdate><title>Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis</title><author>Rajendran, Peramaiyan ; Jayakumar, Thangavel ; Nishigaki, Ikuo ; Ekambaram, Ganapathy ; Nishigaki, Yutaka ; Vetriselvi, Jayabal ; Sakthisekaran, Dhanapal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-b9842a41eb49ee7163f64805662ff3908a8f85fb76bcb226524b85704178a90e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Rajendran, Peramaiyan</creatorcontrib><creatorcontrib>Jayakumar, Thangavel</creatorcontrib><creatorcontrib>Nishigaki, Ikuo</creatorcontrib><creatorcontrib>Ekambaram, Ganapathy</creatorcontrib><creatorcontrib>Nishigaki, Yutaka</creatorcontrib><creatorcontrib>Vetriselvi, Jayabal</creatorcontrib><creatorcontrib>Sakthisekaran, Dhanapal</creatorcontrib><creatorcontrib>NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan</creatorcontrib><creatorcontrib>Department of Pharmacology and Environmental Toxicology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</creatorcontrib><creatorcontrib>Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</creatorcontrib><creatorcontrib>Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi, Thanjavur, India</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of biomedical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajendran, Peramaiyan</au><au>Jayakumar, Thangavel</au><au>Nishigaki, Ikuo</au><au>Ekambaram, Ganapathy</au><au>Nishigaki, Yutaka</au><au>Vetriselvi, Jayabal</au><au>Sakthisekaran, Dhanapal</au><aucorp>NPO-International Laboratory of Biochemistry, 1-166, Uchide, Nakagawa-ku, Nagoya 454-0926, Japan</aucorp><aucorp>Department of Pharmacology and Environmental Toxicology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</aucorp><aucorp>Department of Medical Biochemistry, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India</aucorp><aucorp>Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi, Thanjavur, India</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis</atitle><jtitle>International journal of biomedical science</jtitle><addtitle>Int J Biomed Sci</addtitle><date>2013-06</date><risdate>2013</risdate><volume>9</volume><issue>2</issue><spage>68</spage><epage>74</epage><pages>68-74</pages><issn>1550-9702</issn><eissn>1555-2810</eissn><abstract><![CDATA[The immunomodulatory activity of mangiferin was studied in various groups of animals. For this study, adult Swiss albino male mice were treated with benzo(a)pyrene, abbreviated as B(a)P, at 50 mg/kg body weight orally twice a week for 4 weeks; and mangiferin was also given orally (pre- and post-initiation of carcinoma) at 100 mg/kg body weight. Immunocompetence and immune complexes as measured by phagocyte index, avidity index, and soluble immune complex (SIC) levels (p<0.001), as well as NBT reduction, were decreased in the B(a)P-treated animals;whereas increased levels of immunocompetence were noted in the mangiferin-treated animals given B(a)P (p<0.001, p<0.05). The levels of immunoglobulins such as IgG and IgM were decreased considerably (p<0.001) in the B(a)P-treated animals compared with their levels in the control animals; whereas the IgA level was increased (p<0.001). In the mangiferin-treated experimental animals given B(a)P, the levels of IgG and IgM were significantly (p<0.001, p<0.05) increased whereas the IgA level was decreased compared with those for the B(a)P-treated mice. Oxidative changes in lymphocytes, neutrophils, and macrophages were also measured. The enhanced lipid peroxidation and decreased catalase and superoxide dismutase activities found in the lymphocytes, polymorphonuclear cells (PMN), and macrophages from B(a)P-treated mice were significantly reduced and increased, respectively, by the mangiferin treatment. This study confirms the immunomodulatory effect of mangiferin and shows an immunoprotective role arbitrated through a reduction in the reactive intermediate-induced oxidative stress in lymphocytes, neutrophils, and macrophages.]]></abstract><cop>United States</cop><pub>Master Publishing Group</pub><pmid>23847456</pmid><doi>10.59566/IJBS.2013.9068</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-9702 |
| ispartof | International journal of biomedical science, 2013-06, Vol.9 (2), p.68-74 |
| issn | 1550-9702 1555-2810 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3708270 |
| source | PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Original |
| title | Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T15%3A54%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunomodulatory%20Effect%20of%20Mangiferin%20in%20Experimental%20Animals%20with%20Benzo(a)Pyrene-induced%20Lung%20Carcinogenesis&rft.jtitle=International%20journal%20of%20biomedical%20science&rft.au=Rajendran,%20Peramaiyan&rft.aucorp=NPO-International%20Laboratory%20of%20Biochemistry,%201-166,%20Uchide,%20Nakagawa-ku,%20Nagoya%20454-0926,%20Japan&rft.date=2013-06&rft.volume=9&rft.issue=2&rft.spage=68&rft.epage=74&rft.pages=68-74&rft.issn=1550-9702&rft.eissn=1555-2810&rft_id=info:doi/10.59566/IJBS.2013.9068&rft_dat=%3Cpubmed_cross%3E23847456%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23847456&rfr_iscdi=true |