Extending the Mannose 6-Phosphate Glycoproteome by High Resolution/Accuracy Mass Spectrometry Analysis of Control and Acid Phosphatase 5-Deficient Mice

In mammals, most newly synthesized lumenal lysosomal proteins are delivered to the lysosome by the mannose 6-phosphate (Man6P) targeting pathway. Man6P -containing proteins can be affinity-purified and characterized using proteomic approaches, and such studies have led to the discovery of new lysoso...

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Veröffentlicht in:	Molecular & cellular proteomics 2013-07, Vol.12 (7), p.1806-1817
Hauptverfasser:	Sleat, David E., Sun, Pengling, Wiseman, Jennifer A., Huang, Ling, El-Banna, Mukarram, Zheng, Haiyan, Moore, Dirk F., Lobel, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - genetics Acid Phosphatase - metabolism Animals Isoenzymes - genetics Isoenzymes - metabolism Lysosomes - metabolism Mannosephosphates - metabolism Mice Mice, Knockout Proteome Tandem Mass Spectrometry - methods Tartrate-Resistant Acid Phosphatase
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