Increased Rho kinase activity in congestive heart failure

Aims Rho kinases (ROCKs) are the best characterized effectors of the small G‐protein RhoA, and play a role in enhanced vasoconstriction in animal models of congestive heart failure (CHF). This study examined if ROCK activity is increased in CHF and how it is associated with the outcome in CHF. Metho...

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Veröffentlicht in:	European journal of heart failure 2012-09, Vol.14 (9), p.965-973
Hauptverfasser:	Dong, Ming, Liao, James K., Fang, Fang, Lee, Alex Pui-Wai, Yan, Bryan Ping-Yen, Liu, Ming, Yu, Cheuk-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers Blotting, Western Case-Control Studies congestive heart failure Dyspnea - enzymology Female Follow-Up Studies Heart Failure - complications Heart Failure - enzymology Heart Failure - mortality Humans Male Middle Aged mortality Natriuretic Peptide, Brain - metabolism Peptide Fragments - metabolism Prognosis rho kinases rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism Risk Factors Stroke Volume
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