Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice
LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. In this study, we show that LZ-8 induces the expansion of both murine and human CD4+ T cells into FOXP3+ regulatory T (Tr...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-11 |
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| creator | Hsu, Hsien-Yeh Kuan, Yen-Chou Lin, Tung-Yi Tsao, Shu-Ming Hsu, Jason Ma, Li-Juan Sheu, Fuu |
| description | LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. In this study, we show that LZ-8 induces the expansion of both murine and human CD4+ T cells into FOXP3+ regulatory T (Treg) cells. LZ-8 treatment was found to stimulate a 4-fold and a 10-fold expansion in the Treg populations of murine and human primary CD4+ T cells, respectively. In addition, the expression of CTLA-4 and IL-10 was induced in LZ-8-treated CD4+ T cells. Using neutralizing antibodies and gene-deficient T-cell lines, we also found that LZ-8 promotes Treg expansion through a CD45-mediated signaling pathway and that the CD18-dependent induction of IL-2 was involved in Treg formation and IL-10 production. The suppressive activity of LZ-8 was confirmed using a murine model of DSS-induced colitis; the disease was alleviated by the adoptive transfer of LZ-8-treated CD4+ T cells. In conclusion, a new regulatory function for LZ-8 was identified, and the molecular mechanisms underlying this function were elucidated. |
| doi_str_mv | 10.1155/2013/513542 |
| format | Article |
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In this study, we show that LZ-8 induces the expansion of both murine and human CD4+ T cells into FOXP3+ regulatory T (Treg) cells. LZ-8 treatment was found to stimulate a 4-fold and a 10-fold expansion in the Treg populations of murine and human primary CD4+ T cells, respectively. In addition, the expression of CTLA-4 and IL-10 was induced in LZ-8-treated CD4+ T cells. Using neutralizing antibodies and gene-deficient T-cell lines, we also found that LZ-8 promotes Treg expansion through a CD45-mediated signaling pathway and that the CD18-dependent induction of IL-2 was involved in Treg formation and IL-10 production. The suppressive activity of LZ-8 was confirmed using a murine model of DSS-induced colitis; the disease was alleviated by the adoptive transfer of LZ-8-treated CD4+ T cells. In conclusion, a new regulatory function for LZ-8 was identified, and the molecular mechanisms underlying this function were elucidated.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/513542</identifier><identifier>PMID: 23864893</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adoptive transfer ; Animal models ; CD18 antigen ; CD4 antigen ; CD45 antigen ; Cell growth ; Cell lines ; Cell proliferation ; Colitis ; CTLA-4 protein ; Cytokines ; Drinking water ; Expansion ; Experiments ; Foxp3 protein ; Ganoderma lucidum ; Growth factors ; Homeostasis ; Immunoglobulins ; Immunology ; Immunomodulation ; Inflammation ; Inflammatory bowel disease ; Interleukin 10 ; Interleukin 2 ; Intestine ; Laboratory animals ; Lymphocytes ; Lymphocytes T ; Molecular modelling ; Mushrooms ; Proteins ; Rodents ; Signal transduction</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-11</ispartof><rights>Copyright © 2013 Hsien-Yeh Hsu et al.</rights><rights>Copyright © 2013 Hsien-Yeh Hsu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Hsien-Yeh Hsu et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c76059fb6dc49c10e1a2b2a690c381e67d08acafe344ab5db6b6caab0db434e33</citedby><cites>FETCH-LOGICAL-c499t-c76059fb6dc49c10e1a2b2a690c381e67d08acafe344ab5db6b6caab0db434e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707273/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707273/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23864893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhang, Ruixin</contributor><contributor>Ruixin Zhang</contributor><creatorcontrib>Hsu, Hsien-Yeh</creatorcontrib><creatorcontrib>Kuan, Yen-Chou</creatorcontrib><creatorcontrib>Lin, Tung-Yi</creatorcontrib><creatorcontrib>Tsao, Shu-Ming</creatorcontrib><creatorcontrib>Hsu, Jason</creatorcontrib><creatorcontrib>Ma, Li-Juan</creatorcontrib><creatorcontrib>Sheu, Fuu</creatorcontrib><title>Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. 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In conclusion, a new regulatory function for LZ-8 was identified, and the molecular mechanisms underlying this function were elucidated.</description><subject>Adoptive transfer</subject><subject>Animal models</subject><subject>CD18 antigen</subject><subject>CD4 antigen</subject><subject>CD45 antigen</subject><subject>Cell growth</subject><subject>Cell lines</subject><subject>Cell proliferation</subject><subject>Colitis</subject><subject>CTLA-4 protein</subject><subject>Cytokines</subject><subject>Drinking water</subject><subject>Expansion</subject><subject>Experiments</subject><subject>Foxp3 protein</subject><subject>Ganoderma lucidum</subject><subject>Growth factors</subject><subject>Homeostasis</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Interleukin 10</subject><subject>Interleukin 2</subject><subject>Intestine</subject><subject>Laboratory animals</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Molecular modelling</subject><subject>Mushrooms</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Signal 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factors</topic><topic>Homeostasis</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Interleukin 10</topic><topic>Interleukin 2</topic><topic>Intestine</topic><topic>Laboratory animals</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Molecular modelling</topic><topic>Mushrooms</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Hsien-Yeh</creatorcontrib><creatorcontrib>Kuan, Yen-Chou</creatorcontrib><creatorcontrib>Lin, Tung-Yi</creatorcontrib><creatorcontrib>Tsao, Shu-Ming</creatorcontrib><creatorcontrib>Hsu, Jason</creatorcontrib><creatorcontrib>Ma, Li-Juan</creatorcontrib><creatorcontrib>Sheu, Fuu</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical 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Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells. In this study, we show that LZ-8 induces the expansion of both murine and human CD4+ T cells into FOXP3+ regulatory T (Treg) cells. LZ-8 treatment was found to stimulate a 4-fold and a 10-fold expansion in the Treg populations of murine and human primary CD4+ T cells, respectively. In addition, the expression of CTLA-4 and IL-10 was induced in LZ-8-treated CD4+ T cells. Using neutralizing antibodies and gene-deficient T-cell lines, we also found that LZ-8 promotes Treg expansion through a CD45-mediated signaling pathway and that the CD18-dependent induction of IL-2 was involved in Treg formation and IL-10 production. The suppressive activity of LZ-8 was confirmed using a murine model of DSS-induced colitis; the disease was alleviated by the adoptive transfer of LZ-8-treated CD4+ T cells. In conclusion, a new regulatory function for LZ-8 was identified, and the molecular mechanisms underlying this function were elucidated.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23864893</pmid><doi>10.1155/2013/513542</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adoptive transfer Animal models CD18 antigen CD4 antigen CD45 antigen Cell growth Cell lines Cell proliferation Colitis CTLA-4 protein Cytokines Drinking water Expansion Experiments Foxp3 protein Ganoderma lucidum Growth factors Homeostasis Immunoglobulins Immunology Immunomodulation Inflammation Inflammatory bowel disease Interleukin 10 Interleukin 2 Intestine Laboratory animals Lymphocytes Lymphocytes T Molecular modelling Mushrooms Proteins Rodents Signal transduction |
| title | Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice |
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