Genomic Insights into the Immune System of the Sea Urchin

Comparative analysis of the sea urchin genome has broad implications for the primitive state of deuterostome host defense and the genetic underpinnings of immunity in vertebrates. The sea urchin has an unprecedented complexity of innate immune recognition receptors relative to other animal species y...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-11, Vol.314 (5801), p.952-956
Hauptverfasser:	Rast, Jonathan P, Smith, L. Courtney, Loza-Coll, Mariano, Hibino, Taku, Litman, Gary W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquatic life Bilateria Chordata Comparative analysis DNA-Binding Proteins - genetics Echinoidea Evolution Evolution, Molecular Gene Expression Regulation Genes Genes, Immunoglobulin Genes, RAG-1 Genome Genomes Genomics Immune system Immune System - physiology Immunity Immunity, Innate - genetics Immunoglobulins Immunologic Factors - genetics Immunologic Factors - physiology Marine Multigene Family Phylogeny Receptors Receptors, Immunologic - genetics Receptors, Immunologic - physiology Receptors, Pattern Recognition - genetics Review Sea urchins Strongylocentrotus purpuratus - genetics Strongylocentrotus purpuratus - immunology Toll-Like Receptors - genetics Toll-Like Receptors - physiology Vertebrates Vertebrates - genetics Vertebrates - immunology
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