Using VIPT‑Jump to Distinguish Between Different Folding Mechanisms: Application to BBL and a Trpzip

Protein folding involves a large number of sequential molecular steps or conformational substates. Thus, experimental characterization of the underlying folding energy landscape for any given protein is difficult. Herein, we present a new method that can be used to determine the major characteristic...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-05, Vol.135 (20), p.7668-7673
Hauptverfasser:	Lin, Chun-Wei, Culik, Robert M, Gai, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	diffusivity Escherichia coli Proteins - chemistry Gibbs free energy methodology Protein Folding Temperature tryptophan Tryptophan - chemical synthesis Tryptophan - chemistry
Online-Zugang:	Volltext
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