Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

Ten-Eleven Translocation (Tet) family of dioxygenases dynamically regulates DNA methylation and has been implicated in cell lineage differentiation and oncogenesis. Yet their functions and mechanisms of action in gene regulation and embryonic development are largely unknown. Here, we report that Xen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2012-12, Vol.151 (6), p.1200-1213
Hauptverfasser:	Xu, Yufei, Xu, Chao, Kato, Akiko, Tempel, Wolfram, Abreu, Jose Garcia, Bian, Chuanbing, Hu, Yeguang, Hu, Di, Zhao, Bin, Cerovina, Tanja, Diao, Jianbo, Wu, Feizhen, He, Housheng Hansen, Cui, Qingyan, Clark, Erin, Ma, Chun, Barbara, Andrew, Veenstra, Gert Jan C., Xu, Guoliang, Kaiser, Ursula B., Liu, X. Shirley, Sugrue, Stephen P., He, Xi, Min, Jinrong, Kato, Yoichi, Shi, Yujiang Geno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carcinogenesis Dioxygenases - chemistry Dioxygenases - genetics Dioxygenases - metabolism DNA DNA methylation DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism embryogenesis enzyme activity Eye - embryology eyes gene expression gene expression regulation genes mechanism of action Molecular Sequence Data neurodevelopment Neurogenesis Promoter Regions, Genetic Protein Structure, Tertiary transcription factors Xenopus Xenopus laevis - embryology Xenopus laevis - metabolism Xenopus Proteins - chemistry Xenopus Proteins - genetics Xenopus Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!