Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study
The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2013, Vol.53(1), pp.36-40 |
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| creator | Khajehnasiri, Farahnaz Mortazavi, Seyed Bagher Allameh, Abdolamir Akhondzadeh, Shahin |
| description | The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p |
| doi_str_mv | 10.3164/jcbn.12-98 |
| format | Article |
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The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p<0.05). Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01). Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone. (Registration number: IRCT201202189056N1)</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.12-98</identifier><identifier>PMID: 23874068</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>depression ; high sensitivity C-reactive protein (hs-CRP) ; interleukin-6 (IL-6) ; omega-3 fatty acids ; Original ; vitamin C</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2013, Vol.53(1), pp.36-40</ispartof><rights>2013 JCBN</rights><rights>Copyright © 2013 JCBN 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c626t-8afdceb770abd4f29880be4584925b965c2d22d539e8f132d18b7db815a4005a3</citedby><cites>FETCH-LOGICAL-c626t-8afdceb770abd4f29880be4584925b965c2d22d539e8f132d18b7db815a4005a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705155/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705155/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1876,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23874068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khajehnasiri, Farahnaz</creatorcontrib><creatorcontrib>Mortazavi, Seyed Bagher</creatorcontrib><creatorcontrib>Allameh, Abdolamir</creatorcontrib><creatorcontrib>Akhondzadeh, Shahin</creatorcontrib><title>Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p<0.05). Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01). Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone. (Registration number: IRCT201202189056N1)</description><subject>depression</subject><subject>high sensitivity C-reactive protein (hs-CRP)</subject><subject>interleukin-6 (IL-6)</subject><subject>omega-3 fatty acids</subject><subject>Original</subject><subject>vitamin C</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpVkc-OFCEQxonRuOPqxQcwnI29At300B7Mms2qm2yyia5nUvybZqRhAj2a8a18QxlHO3qhQn1f_aqgEHpOyUVL--71Vqt4QVkziAdoRYUgDSeif4hWZKhZQshwhp6UsiWk63nfPUZnrBXrjvRihX5eO2f1jJPDabIbaFoM0WAoOmXlNQbtDU4R--gCTBPMvl4myF9tLjWJjd1lW4o1uIzezfh7WqTPI4y1-D5Fs0kHiPjOB_zJOh9tPrzCNxniGwy4BpMm_6MiTNqrYBsVfB1hF0BblRqd4pxTCMcW894cnqJHDkKxz_7Ec_Tl_fX91cfm9u7DzdW720b3rJ8bAc7U-vWagDKdY0P9F2U7LrqBcTX0XDPDmOHtYIWjLTNUqLVRgnLoCOHQnqO3J-5uryZbWXUMCHKXfX3-QSbw8n8l-lFu0jfZrgmnnFfAyxNA51RKtm6ppUQeFyePi5OUyUFU84t_uy3Wv5uqhsuTYVtm2NjFAHn2OtgTi7eS_j6OzEXSI2RpY_sL-wmwrw</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Khajehnasiri, Farahnaz</creator><creator>Mortazavi, Seyed Bagher</creator><creator>Allameh, Abdolamir</creator><creator>Akhondzadeh, Shahin</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study</title><author>Khajehnasiri, Farahnaz ; Mortazavi, Seyed Bagher ; Allameh, Abdolamir ; Akhondzadeh, Shahin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c626t-8afdceb770abd4f29880be4584925b965c2d22d539e8f132d18b7db815a4005a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>depression</topic><topic>high sensitivity C-reactive protein (hs-CRP)</topic><topic>interleukin-6 (IL-6)</topic><topic>omega-3 fatty acids</topic><topic>Original</topic><topic>vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khajehnasiri, Farahnaz</creatorcontrib><creatorcontrib>Mortazavi, Seyed Bagher</creatorcontrib><creatorcontrib>Allameh, Abdolamir</creatorcontrib><creatorcontrib>Akhondzadeh, Shahin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khajehnasiri, Farahnaz</au><au>Mortazavi, Seyed Bagher</au><au>Allameh, Abdolamir</au><au>Akhondzadeh, Shahin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2013</date><risdate>2013</risdate><volume>53</volume><issue>1</issue><spage>36</spage><epage>40</epage><pages>36-40</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery. The study design was randomized, double-blind, placebo-controlled, parallel trial. Totally 136 shift workers with a depression score ≥10 in 21-item Beck Depression Rating Scale were randomly assigned to receive omega-3 (180 mg eicosapentaenoate acid and 120 mg docosahexaenoic acid) or/and vitamin C 250 mg or placebo twice daily (with the same taste and shape as omega-3 and vitamin C) for 60 days in four groups. Depression score, interleukin-6 and high sensitivity C-reactive protein were measured at baseline and after 60 days. This study showed that supplementation of omega-3 plus vitamin C is associated with a decrease in depression score (p<0.05). Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01). Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone. (Registration number: IRCT201202189056N1)</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>23874068</pmid><doi>10.3164/jcbn.12-98</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Clinical Biochemistry and Nutrition, 2013, Vol.53(1), pp.36-40 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | depression high sensitivity C-reactive protein (hs-CRP) interleukin-6 (IL-6) omega-3 fatty acids Original vitamin C |
| title | Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study |
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