Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies
To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parki...
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| Veröffentlicht in: | Journal of neurology 2013-07, Vol.260 (7), p.1731-1742 |
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| creator | Onofrj, Marco Varanese, Sara Bonanni, Laura Taylor, John-Paul Antonini, Angelo Valente, Enza Maria Petrucci, Simona Stocchi, Fabrizio Thomas, Astrid Perfetti, Bernardo |
| description | To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parkinson’s Disease (PD) and 34 Essential Tremor (ET) patients. Tremulous DLB patients (tDLB) were compared with tremulous PD (tPD) and ET patients and followed for 2 years. Double blind placebo-controlled acute drug challenge with
l
-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (
p
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| doi_str_mv | 10.1007/s00415-013-6853-y |
| format | Article |
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l
-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (
p
< 0.001). Head tremor was more frequent in tDLB than tPD and ET (
p
= 0.001). The tDLB tremors were reduced by acute and chronic dopaminergic treatments (
p
< 0.01) but not by alcohol or primidone. Tremor occurs commonly in DLB patients with a complex mixed tremor pattern which shows a significant response to acute and chronic dopaminergic treatments. Recognizing that there is a clinical category of tremulous DLB may help the differential diagnosis of tremors.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-013-6853-y</identifier><identifier>PMID: 23400498</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Antiparkinson Agents - therapeutic use ; Cohort analysis ; Comorbidity ; Dementia ; Dementia disorders ; Dopamine ; Double-Blind Method ; Female ; Humans ; Levodopa - therapeutic use ; Lewy Body Disease - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Movement disorders ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Parkinson's disease ; Phenomenology ; Prevalence ; Severity of Illness Index ; Treatment Outcome ; Tremor (Muscular contraction) ; Tremor - drug therapy ; Tremor - epidemiology</subject><ispartof>Journal of neurology, 2013-07, Vol.260 (7), p.1731-1742</ispartof><rights>The Author(s) 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-662443a4e6edfe2b2ce9b8757b0a0a9d8afbb16f74589809a8d9a63723cfddd63</citedby><cites>FETCH-LOGICAL-c536t-662443a4e6edfe2b2ce9b8757b0a0a9d8afbb16f74589809a8d9a63723cfddd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-013-6853-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-013-6853-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23400498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onofrj, Marco</creatorcontrib><creatorcontrib>Varanese, Sara</creatorcontrib><creatorcontrib>Bonanni, Laura</creatorcontrib><creatorcontrib>Taylor, John-Paul</creatorcontrib><creatorcontrib>Antonini, Angelo</creatorcontrib><creatorcontrib>Valente, Enza Maria</creatorcontrib><creatorcontrib>Petrucci, Simona</creatorcontrib><creatorcontrib>Stocchi, Fabrizio</creatorcontrib><creatorcontrib>Thomas, Astrid</creatorcontrib><creatorcontrib>Perfetti, Bernardo</creatorcontrib><title>Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>To study prevalence, specific patterns and response to treatment of tremor in dementia with Lewy bodies (DLB), in comparison with other tremulous disorders prevalence, qualitative and quantitative features of tremor were studied in an incident cohort of 67 dopaminergic treatment naive DLB, 111 Parkinson’s Disease (PD) and 34 Essential Tremor (ET) patients. Tremulous DLB patients (tDLB) were compared with tremulous PD (tPD) and ET patients and followed for 2 years. Double blind placebo-controlled acute drug challenge with
l
-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (
p
< 0.001). Head tremor was more frequent in tDLB than tPD and ET (
p
= 0.001). The tDLB tremors were reduced by acute and chronic dopaminergic treatments (
p
< 0.01) but not by alcohol or primidone. Tremor occurs commonly in DLB patients with a complex mixed tremor pattern which shows a significant response to acute and chronic dopaminergic treatments. Recognizing that there is a clinical category of tremulous DLB may help the differential diagnosis of tremors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Cohort analysis</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Dopamine</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Lewy Body Disease - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Parkinson's disease</subject><subject>Phenomenology</subject><subject>Prevalence</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><subject>Tremor (Muscular contraction)</subject><subject>Tremor - drug therapy</subject><subject>Tremor - epidemiology</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9v1DAQxS0EokvhA3BBlrhwCYz_xr4goVUpSCtxAM6WE092UyXxYiet8u1xu6UqSBwsS36_eTPjR8hrBu8ZQP0hA0imKmCi0kaJan1CNkwKXjGp7FOyASGhUkLJM_Ii5ysAMEV4Ts54EUBasyHft_EQ00zzvISVxo4eE177AacWqZ8CPR5wimM5Q9zf6XPCMSbaTzRgeZ97T2_6-UB3eLPSJoYe80vyrPNDxlf39zn5-fnix_ZLtft2-XX7aVe1Sui50ppLKbxEjaFD3vAWbWNqVTfgwdtgfNc0THe1VMYasN4E67WouWi7EIIW5-Tjyfe4NCOGtkyT_OCOqR99Wl30vftbmfqD28drJ2pQ5YuKwbt7gxR_LZhnN_a5xWHwE8YlOyYZV1pwYwv69h_0Ki5pKus5JqzRTAgBhWInqk0x54TdwzAM3G1k7hSZK5G528jcWmrePN7ioeJPRgXgJyAXadpjetT6v66_AW3uo3g</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Onofrj, Marco</creator><creator>Varanese, Sara</creator><creator>Bonanni, Laura</creator><creator>Taylor, John-Paul</creator><creator>Antonini, Angelo</creator><creator>Valente, Enza Maria</creator><creator>Petrucci, Simona</creator><creator>Stocchi, Fabrizio</creator><creator>Thomas, Astrid</creator><creator>Perfetti, Bernardo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130701</creationdate><title>Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies</title><author>Onofrj, Marco ; 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Tremulous DLB patients (tDLB) were compared with tremulous PD (tPD) and ET patients and followed for 2 years. Double blind placebo-controlled acute drug challenge with
l
-Dopa and alcohol was performed in all ET, 24 tDLB and 27 tPD. Effects of dopaminergic chronic treatment in all tDLB and tPD patients and primidone in 8 tDLB were also assessed. Tremor occurred in 44.76 % of DLB patients. The tDLB patients presented a complex pattern of mixed tremors, characterized by rest and postural/action tremor, including walking tremor and standing overflow in 50 % tDLB. Standing tremor with overflow was characteristic of tDLB (
p
< 0.001). Head tremor was more frequent in tDLB than tPD and ET (
p
= 0.001). The tDLB tremors were reduced by acute and chronic dopaminergic treatments (
p
< 0.01) but not by alcohol or primidone. Tremor occurs commonly in DLB patients with a complex mixed tremor pattern which shows a significant response to acute and chronic dopaminergic treatments. Recognizing that there is a clinical category of tremulous DLB may help the differential diagnosis of tremors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23400498</pmid><doi>10.1007/s00415-013-6853-y</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, 2013-07, Vol.260 (7), p.1731-1742 |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Aged Aged, 80 and over Antiparkinson Agents - therapeutic use Cohort analysis Comorbidity Dementia Dementia disorders Dopamine Double-Blind Method Female Humans Levodopa - therapeutic use Lewy Body Disease - epidemiology Male Medicine Medicine & Public Health Middle Aged Movement disorders Neurology Neuroradiology Neurosciences Original Communication Parkinson's disease Phenomenology Prevalence Severity of Illness Index Treatment Outcome Tremor (Muscular contraction) Tremor - drug therapy Tremor - epidemiology |
| title | Cohort study of prevalence and phenomenology of tremor in dementia with Lewy bodies |
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