Linkage and association of successful aging to the 6q25 region in large Amish kindreds

Successful aging (SA) is a multidimensional phenotype involving living to older age with high physical function, preserved cognition, and continued social engagement. Several domains underlying SA are heritable, and identifying health-promoting polymorphisms and their interactions with the environme...

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Veröffentlicht in:	AGE 2013-08, Vol.35 (4), p.1467-1477
Hauptverfasser:	Edwards, Digna R. Velez, Gilbert, John R., Hicks, James E., Myers, Jamie L., Jiang, Lan, Cummings, Anna C., Guo, Shengru, Gallins, Paul J., Konidari, Ioanna, Caywood, Laura, Reinhart-Mercer, Lori, Fuzzell, Denise, Knebusch, Claire, Laux, Renee, Jackson, Charles E., Pericak-Vance, Margaret A., Haines, Jonathan L., Scott, William K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Aging Aging - genetics Amish - genetics Amish culture Biomedical and Life Sciences Cell Biology Centenarians Chromosome Mapping Chromosomes, Human, Pair 6 - genetics Cognition & reasoning Dementia Dementia - ethnology Dementia - genetics Economic statistics Epidemiology Female Genetic Linkage - genetics Genetics Genome-Wide Association Study Genomes Genomics Genotype & phenotype Geriatrics/Gerontology Health care Humans Immigration Incidence Indiana - epidemiology Life expectancy Life Sciences Lod Score Male Medical research Middle Aged Molecular Medicine Ohio - epidemiology Older people Oldest old people Pedigree Phenotype Polymorphism Polymorphism, Single Nucleotide Population Prospective Studies Public health Statistical analysis Studies
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