Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study
Background: The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported. Methods: Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2013-07, Vol.23 (7), p.879-884 |
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| container_title | Thyroid (New York, N.Y.) |
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| creator | Chen, Yen-Kung Lin, Cheng-Li Chang, Yen-Jung Cheng, Fiona Tsui-Fen Peng, Chiao-Ling Sung, Fung-Chang Cheng, Ya-Hsin Kao, Chia-Hung |
| description | Background:
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
Methods:
Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
Results:
The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (
p |
| doi_str_mv | 10.1089/thy.2012.0568 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3704114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1399263822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-52e578a4f4f5dd7019df104d2f658115d542806cafacf624b6765dca28fd8db23</originalsourceid><addsrcrecordid>eNqFkMtLAzEQh4MoWh9Hr5KbXrYm2bzWg1CqVqGo-DiHdJPY6Ha3Jqml_727VEVPnmaY-fjN8AFwiFEfI1mcpumqTxAmfcS43AA9zJjICiTEZtsjhjJBGN8BuzG-IoS5FPk22CE5JZhR2QOjoa5LG-CDj2_Q1_BeJ2_rFOHSpykcBf1h4zG88NHqaM_gAN62QFMvvbFw2EybkOBjWpjVPthyuor24Kvugeery6fhdTa-G90MB-OspDlOGSOWCampo44ZIxAujMOIGuI4kxgzwyiRiJfa6dJxQidccGZKTaQz0kxIvgfO17nzxWRmTdn-GnSl5sHPdFipRnv1d1P7qXppPlQuEMWYtgEnXwGheV_YmNTMx9JWla5ts4gK50VBeC5Jdytbo2VoYgzW_ZzBSHXyVStfdfJVJ7_lj37_9kN_226BfA10Y13XlbcTG9I_sZ-ZaZGM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399263822</pqid></control><display><type>article</type><title>Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Chen, Yen-Kung ; Lin, Cheng-Li ; Chang, Yen-Jung ; Cheng, Fiona Tsui-Fen ; Peng, Chiao-Ling ; Sung, Fung-Chang ; Cheng, Ya-Hsin ; Kao, Chia-Hung</creator><creatorcontrib>Chen, Yen-Kung ; Lin, Cheng-Li ; Chang, Yen-Jung ; Cheng, Fiona Tsui-Fen ; Peng, Chiao-Ling ; Sung, Fung-Chang ; Cheng, Ya-Hsin ; Kao, Chia-Hung</creatorcontrib><description>Background:
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
Methods:
Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
Results:
The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (
p
<0.001). Compared with patients aged 20–34 years, older age groups demonstrated a higher risk of developing cancer (35–49 years: hazard ratio (HR)=4.15; 50–64 years: HR=7.39;≥65 years: HR=13.4). After adjusting for sex, age, and comorbidities, the HR for developing breast cancer and thyroid cancer was 1.58- and 10.4-fold higher for patients with GD. Furthermore, the incidence rates (IRR) were the highest in the first three years: 2.06 [confidence interval (CI)=1.87–2.27] and 15.6 [CI=13.9–17.5] in breast cancer and thyroid cancer with GD respectively. Specifically, a 16-fold hazard of developing thyroid cancer was present in the first three years in the GD cohort compared to the non-GD cohort [CI=7.95–32.1].
Conclusions:
GD patients have a higher risk of cancer, particularly thyroid and breast cancer sequent within six and three years respectively. Strategies for preventing thyroid and breast cancer are proposed.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2012.0568</identifier><identifier>PMID: 23421548</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Aged ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Comorbidity ; Epidemiology ; Female ; Graves Disease - complications ; Graves Disease - epidemiology ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Neoplasms - epidemiology ; Neoplasms - etiology ; Proportional Hazards Models ; Risk Factors ; Taiwan - epidemiology ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - etiology</subject><ispartof>Thyroid (New York, N.Y.), 2013-07, Vol.23 (7), p.879-884</ispartof><rights>2013, Mary Ann Liebert, Inc.</rights><rights>Copyright 2013, Mary Ann Liebert, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-52e578a4f4f5dd7019df104d2f658115d542806cafacf624b6765dca28fd8db23</citedby><cites>FETCH-LOGICAL-c431t-52e578a4f4f5dd7019df104d2f658115d542806cafacf624b6765dca28fd8db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23421548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yen-Kung</creatorcontrib><creatorcontrib>Lin, Cheng-Li</creatorcontrib><creatorcontrib>Chang, Yen-Jung</creatorcontrib><creatorcontrib>Cheng, Fiona Tsui-Fen</creatorcontrib><creatorcontrib>Peng, Chiao-Ling</creatorcontrib><creatorcontrib>Sung, Fung-Chang</creatorcontrib><creatorcontrib>Cheng, Ya-Hsin</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><title>Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Background:
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
Methods:
Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
Results:
The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (
p
<0.001). Compared with patients aged 20–34 years, older age groups demonstrated a higher risk of developing cancer (35–49 years: hazard ratio (HR)=4.15; 50–64 years: HR=7.39;≥65 years: HR=13.4). After adjusting for sex, age, and comorbidities, the HR for developing breast cancer and thyroid cancer was 1.58- and 10.4-fold higher for patients with GD. Furthermore, the incidence rates (IRR) were the highest in the first three years: 2.06 [confidence interval (CI)=1.87–2.27] and 15.6 [CI=13.9–17.5] in breast cancer and thyroid cancer with GD respectively. Specifically, a 16-fold hazard of developing thyroid cancer was present in the first three years in the GD cohort compared to the non-GD cohort [CI=7.95–32.1].
Conclusions:
GD patients have a higher risk of cancer, particularly thyroid and breast cancer sequent within six and three years respectively. Strategies for preventing thyroid and breast cancer are proposed.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Comorbidity</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Graves Disease - complications</subject><subject>Graves Disease - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Taiwan - epidemiology</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - etiology</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLAzEQh4MoWh9Hr5KbXrYm2bzWg1CqVqGo-DiHdJPY6Ha3Jqml_727VEVPnmaY-fjN8AFwiFEfI1mcpumqTxAmfcS43AA9zJjICiTEZtsjhjJBGN8BuzG-IoS5FPk22CE5JZhR2QOjoa5LG-CDj2_Q1_BeJ2_rFOHSpykcBf1h4zG88NHqaM_gAN62QFMvvbFw2EybkOBjWpjVPthyuor24Kvugeery6fhdTa-G90MB-OspDlOGSOWCampo44ZIxAujMOIGuI4kxgzwyiRiJfa6dJxQidccGZKTaQz0kxIvgfO17nzxWRmTdn-GnSl5sHPdFipRnv1d1P7qXppPlQuEMWYtgEnXwGheV_YmNTMx9JWla5ts4gK50VBeC5Jdytbo2VoYgzW_ZzBSHXyVStfdfJVJ7_lj37_9kN_226BfA10Y13XlbcTG9I_sZ-ZaZGM</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Chen, Yen-Kung</creator><creator>Lin, Cheng-Li</creator><creator>Chang, Yen-Jung</creator><creator>Cheng, Fiona Tsui-Fen</creator><creator>Peng, Chiao-Ling</creator><creator>Sung, Fung-Chang</creator><creator>Cheng, Ya-Hsin</creator><creator>Kao, Chia-Hung</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130701</creationdate><title>Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study</title><author>Chen, Yen-Kung ; Lin, Cheng-Li ; Chang, Yen-Jung ; Cheng, Fiona Tsui-Fen ; Peng, Chiao-Ling ; Sung, Fung-Chang ; Cheng, Ya-Hsin ; Kao, Chia-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-52e578a4f4f5dd7019df104d2f658115d542806cafacf624b6765dca28fd8db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Comorbidity</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Graves Disease - complications</topic><topic>Graves Disease - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Taiwan - epidemiology</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yen-Kung</creatorcontrib><creatorcontrib>Lin, Cheng-Li</creatorcontrib><creatorcontrib>Chang, Yen-Jung</creatorcontrib><creatorcontrib>Cheng, Fiona Tsui-Fen</creatorcontrib><creatorcontrib>Peng, Chiao-Ling</creatorcontrib><creatorcontrib>Sung, Fung-Chang</creatorcontrib><creatorcontrib>Cheng, Ya-Hsin</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yen-Kung</au><au>Lin, Cheng-Li</au><au>Chang, Yen-Jung</au><au>Cheng, Fiona Tsui-Fen</au><au>Peng, Chiao-Ling</au><au>Sung, Fung-Chang</au><au>Cheng, Ya-Hsin</au><au>Kao, Chia-Hung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>23</volume><issue>7</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Background:
The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported.
Methods:
Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model.
Results:
The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort (
p
<0.001). Compared with patients aged 20–34 years, older age groups demonstrated a higher risk of developing cancer (35–49 years: hazard ratio (HR)=4.15; 50–64 years: HR=7.39;≥65 years: HR=13.4). After adjusting for sex, age, and comorbidities, the HR for developing breast cancer and thyroid cancer was 1.58- and 10.4-fold higher for patients with GD. Furthermore, the incidence rates (IRR) were the highest in the first three years: 2.06 [confidence interval (CI)=1.87–2.27] and 15.6 [CI=13.9–17.5] in breast cancer and thyroid cancer with GD respectively. Specifically, a 16-fold hazard of developing thyroid cancer was present in the first three years in the GD cohort compared to the non-GD cohort [CI=7.95–32.1].
Conclusions:
GD patients have a higher risk of cancer, particularly thyroid and breast cancer sequent within six and three years respectively. Strategies for preventing thyroid and breast cancer are proposed.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>23421548</pmid><doi>10.1089/thy.2012.0568</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Breast Neoplasms - epidemiology Breast Neoplasms - etiology Comorbidity Epidemiology Female Graves Disease - complications Graves Disease - epidemiology Humans Incidence Longitudinal Studies Male Middle Aged Neoplasms - epidemiology Neoplasms - etiology Proportional Hazards Models Risk Factors Taiwan - epidemiology Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology |
| title | Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study |
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