Cancer Risk in Patients with Graves' Disease: A Nationwide Cohort Study

Background: The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported. Methods: Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2013-07, Vol.23 (7), p.879-884
Hauptverfasser:	Chen, Yen-Kung, Lin, Cheng-Li, Chang, Yen-Jung, Cheng, Fiona Tsui-Fen, Peng, Chiao-Ling, Sung, Fung-Chang, Cheng, Ya-Hsin, Kao, Chia-Hung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Breast Neoplasms - epidemiology Breast Neoplasms - etiology Comorbidity Epidemiology Female Graves Disease - complications Graves Disease - epidemiology Humans Incidence Longitudinal Studies Male Middle Aged Neoplasms - epidemiology Neoplasms - etiology Proportional Hazards Models Risk Factors Taiwan - epidemiology Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology
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Zusammenfassung:	Background: The possibility of an association of Graves' disease (GD) with subsequent cancers has been previously reported. Methods: Our study used the Taiwanese National Health Insurance Research Database (NHIRD), which identified 5025 newly diagnosed GD patients from 1997 to 2010, and 20,100 frequency matched non-GD patients. The risk of developing cancer for GD patients was measured using the Cox proportional hazard model. Results: The incidence of developing cancer in the GD cohort was 4.92 per 1000 person-years and was 1.37-fold higher than in the comparison cohort ( p
ISSN:	1050-7256 1557-9077
DOI:	10.1089/thy.2012.0568