Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

Bioactive natural products containing a C-P bond act as mimics of phosphate esters and carboxylic acids, thereby competing with these compounds for active sites of enzymes. Dehydrophos (DHP), a broad-spectrum antibiotic, is a phosphonotripeptide produced by Streptomyces luridus , in which glycine an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (27), p.10952-10957
Hauptverfasser:	Bougioukou, Despina J., Mukherjee, Subha, van der Donk, Wilfred A.
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Alanine - analogs & derivatives Alanine - chemistry Alanine - metabolism Amides Amino acids Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antibiotics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites bioinformatics Biological Sciences Biosynthesis carboxylic acids chemical bonding Dipeptides - biosynthesis Dipeptides - chemistry Enzymes esters Genes, Bacterial hydrolysis leucine Multigene family Peptidyl Transferases - chemistry Peptidyl Transferases - genetics Peptidyl Transferases - metabolism Phosphates Phosphonic acids phosphorous acid Phosphorylation Proteins pyridoxal pyridoxal phosphate pyruvate dehydrogenase (lipoamide) RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Streptomyces - genetics Streptomyces - metabolism Streptomyces luridus Transfer RNA
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