Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues
We have identified tens of thousands of short extrachromosomal circular DNAs (microDNA) in mouse tissues as well as mouse and human cell lines. These microDNAs are 200 to 400 base pairs long, are derived from unique nonrepetitive sequence, and are enriched in the 5'-untranslated regions of gene...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2012-04, Vol.336 (6077), p.82-86 |
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| creator | Shibata, Yoshiyuki Kumar, Pankaj Layer, Ryan Willcox, Smaranda Gagan, Jeffrey R. Griffith, Jack D. Dutta, Anindya |
| description | We have identified tens of thousands of short extrachromosomal circular DNAs (microDNA) in mouse tissues as well as mouse and human cell lines. These microDNAs are 200 to 400 base pairs long, are derived from unique nonrepetitive sequence, and are enriched in the 5'-untranslated regions of genes, exons, and CpG islands. Chromosomal loci that are enriched sources of microDNA in the adult brain are somatically mosaic for microdeletions that appear to arise from the excision of microDNAs. Germline microdeletions identified by the "Thousand Genomes" project may also arise from the excision of microDNAs in the germline lineage. We have thus identified a previously unknown DNA entity in mammalian cells and provide evidence that their generation leaves behind deletions in different genomic loci. |
| doi_str_mv | 10.1126/science.1213307 |
| format | Article |
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These microDNAs are 200 to 400 base pairs long, are derived from unique nonrepetitive sequence, and are enriched in the 5'-untranslated regions of genes, exons, and CpG islands. Chromosomal loci that are enriched sources of microDNA in the adult brain are somatically mosaic for microdeletions that appear to arise from the excision of microDNAs. Germline microdeletions identified by the "Thousand Genomes" project may also arise from the excision of microDNAs in the germline lineage. We have thus identified a previously unknown DNA entity in mammalian cells and provide evidence that their generation leaves behind deletions in different genomic loci.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1213307</identifier><identifier>PMID: 22403181</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>5' Untranslated Regions ; adults ; Animals ; Base Pairing ; Base Sequence ; Biological and medical sciences ; Brain ; Brain - embryology ; Brain Chemistry ; Cell Line ; Cell Line, Tumor ; Cell lines ; Chromosome Deletion ; Chromosomes ; Chromosomes, Human - genetics ; Chromosomes, Mammalian - genetics ; Circular DNA ; Classical genetics, quantitative genetics, hybrids ; CpG Islands ; Deoxyribonucleic acid ; DNA ; DNA Replication ; DNA, Circular - analysis ; DNA, Circular - chemistry ; DNA, Circular - isolation & purification ; DNA, Circular - metabolism ; Eukaryotes ; Exons ; Fundamental and applied biological sciences. Psychology ; Genetic loci ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; genomic islands ; Genomics ; Germ cells ; Germ Cells - chemistry ; Heart - embryology ; human cell lines ; Humans ; Libraries ; Liver - chemistry ; Liver - embryology ; loci ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron ; Molecular Sequence Data ; Polymerase Chain Reaction ; Repetitive Sequences, Nucleic Acid ; Somatic cells ; Tissues ; Vertebrata</subject><ispartof>Science (American Association for the Advancement of Science), 2012-04, Vol.336 (6077), p.82-86</ispartof><rights>Copyright © 2012 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-2dca77b2d93ea77ddd5401327879ff8ba584f2a5d0e616deaeca4e9cab732a283</citedby><cites>FETCH-LOGICAL-c649t-2dca77b2d93ea77ddd5401327879ff8ba584f2a5d0e616deaeca4e9cab732a283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41508344$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41508344$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25790803$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22403181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shibata, Yoshiyuki</creatorcontrib><creatorcontrib>Kumar, Pankaj</creatorcontrib><creatorcontrib>Layer, Ryan</creatorcontrib><creatorcontrib>Willcox, Smaranda</creatorcontrib><creatorcontrib>Gagan, Jeffrey R.</creatorcontrib><creatorcontrib>Griffith, Jack D.</creatorcontrib><creatorcontrib>Dutta, Anindya</creatorcontrib><title>Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>We have identified tens of thousands of short extrachromosomal circular DNAs (microDNA) in mouse tissues as well as mouse and human cell lines. These microDNAs are 200 to 400 base pairs long, are derived from unique nonrepetitive sequence, and are enriched in the 5'-untranslated regions of genes, exons, and CpG islands. Chromosomal loci that are enriched sources of microDNA in the adult brain are somatically mosaic for microdeletions that appear to arise from the excision of microDNAs. Germline microdeletions identified by the "Thousand Genomes" project may also arise from the excision of microDNAs in the germline lineage. We have thus identified a previously unknown DNA entity in mammalian cells and provide evidence that their generation leaves behind deletions in different genomic loci.</description><subject>5' Untranslated Regions</subject><subject>adults</subject><subject>Animals</subject><subject>Base Pairing</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - embryology</subject><subject>Brain Chemistry</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Cell lines</subject><subject>Chromosome Deletion</subject><subject>Chromosomes</subject><subject>Chromosomes, Human - genetics</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Circular DNA</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>CpG Islands</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Replication</subject><subject>DNA, Circular - analysis</subject><subject>DNA, Circular - chemistry</subject><subject>DNA, Circular - isolation & purification</subject><subject>DNA, Circular - metabolism</subject><subject>Eukaryotes</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. 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These microDNAs are 200 to 400 base pairs long, are derived from unique nonrepetitive sequence, and are enriched in the 5'-untranslated regions of genes, exons, and CpG islands. Chromosomal loci that are enriched sources of microDNA in the adult brain are somatically mosaic for microdeletions that appear to arise from the excision of microDNAs. Germline microdeletions identified by the "Thousand Genomes" project may also arise from the excision of microDNAs in the germline lineage. We have thus identified a previously unknown DNA entity in mammalian cells and provide evidence that their generation leaves behind deletions in different genomic loci.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>22403181</pmid><doi>10.1126/science.1213307</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2012-04, Vol.336 (6077), p.82-86 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | 5' Untranslated Regions adults Animals Base Pairing Base Sequence Biological and medical sciences Brain Brain - embryology Brain Chemistry Cell Line Cell Line, Tumor Cell lines Chromosome Deletion Chromosomes Chromosomes, Human - genetics Chromosomes, Mammalian - genetics Circular DNA Classical genetics, quantitative genetics, hybrids CpG Islands Deoxyribonucleic acid DNA DNA Replication DNA, Circular - analysis DNA, Circular - chemistry DNA, Circular - isolation & purification DNA, Circular - metabolism Eukaryotes Exons Fundamental and applied biological sciences. Psychology Genetic loci Genetics of eukaryotes. Biological and molecular evolution Genomes genomic islands Genomics Germ cells Germ Cells - chemistry Heart - embryology human cell lines Humans Libraries Liver - chemistry Liver - embryology loci Mice Mice, Inbred C57BL Microscopy, Electron Molecular Sequence Data Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid Somatic cells Tissues Vertebrata |
| title | Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues |
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