To charge or not to charge: mechanistic insights into neuropathy-associated tRNA synthetase mutations

Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes responsible for the first step of protein translation — attaching amino acids to cognate tRNA molecules. Interestingly, ARS gene mutations have been implicated in tissue-specific human diseases, including inherited perip...

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Veröffentlicht in:	Current opinion in genetics & development 2013-06, Vol.23 (3), p.302-309
Hauptverfasser:	Wallen, Rachel C, Antonellis, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - genetics Charcot-Marie-Tooth Disease - enzymology Charcot-Marie-Tooth Disease - etiology Charcot-Marie-Tooth Disease - genetics Humans Medical Education Mutation Peripheral Nerves - enzymology Peripheral Nerves - pathology Peripheral Nervous System Diseases - enzymology Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - genetics Phenotype Protein Biosynthesis - genetics
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