MET amplification as a potential therapeutic target in gastric cancer

Our aim was to investigate both the prevalence of MET amplification in gastric cancer as well as the potential of this genetic alteration to serve as a therapeutic target in gastric cancer. MET amplification was assessed by initial screening with a PCR-based copy number assay followed by confirmator...

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Veröffentlicht in:	Oncotarget 2013-01, Vol.4 (1), p.9-17
Hauptverfasser:	Kawakami, Hisato, Okamoto, Isamu, Arao, Tokuzo, Okamoto, Wataru, Matsumoto, Kazuko, Taniguchi, Hirokazu, Kuwata, Kiyoko, Yamaguchi, Haruka, Nishio, Kazuto, Nakagawa, Kazuhiko, Yamada, Yasuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Cell Proliferation - drug effects DNA Copy Number Variations Dose-Response Relationship, Drug Female Gene Amplification Humans Immunoblotting In Situ Hybridization, Fluorescence Male Middle Aged Paraffin Embedding Phosphorylation - drug effects Polymerase Chain Reaction Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Pyridazines - pharmacology Research Paper Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Triazoles - pharmacology
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