Structural basis for R-spondin recognition by LGR4/5/6 receptors

The R-spondin (RSPO) family of secreted proteins (RSPO1-RSPO4) has pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. Recently, leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2013-06, Vol.27 (12), p.1339-1344
Hauptverfasser:	Wang, Dongli, Huang, Binlu, Zhang, Senyan, Yu, Xiaojuan, Wu, Wei, Wang, Xinquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Humans Models, Molecular Molecular Sequence Data Mutation Protein Binding Protein Structure, Tertiary Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Research Communication Sequence Alignment Signal Transduction Thrombospondins - chemistry Thrombospondins - genetics Thrombospondins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!