ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery
Currently, Saphenous vein (SV) and internal thoracic artery (ITA) are still the most common graft materials in Coronary Artery Bypass Grafting (CABG) whereas SV graft have a lower long-term patency than ITA. Vascular smooth muscle cells (VSMCs) phenotype conversion, proliferation and migration may p...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiothoracic surgery 2013-06, Vol.8 (1), p.155-155, Article 155 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 155 |
|---|---|
| container_issue | 1 |
| container_start_page | 155 |
| container_title | Journal of cardiothoracic surgery |
| container_volume | 8 |
| creator | Zhu, Tian-xiang Lan, Bin Meng, Ling-ying Yang, Yan-long Li, Rui-xiong Li, En-min Zheng, Shao-yi Xu, Li-yan |
| description | Currently, Saphenous vein (SV) and internal thoracic artery (ITA) are still the most common graft materials in Coronary Artery Bypass Grafting (CABG) whereas SV graft have a lower long-term patency than ITA. Vascular smooth muscle cells (VSMCs) phenotype conversion, proliferation and migration may play a key role in mechanism of vein graft restenosis. To explore differential gene expression profile in VSMCs from SV and ITA will help to further elucidate the mechanism of VSMCs in vein graft restenosis after CABG and to provide new thread of gene therapy.
VSMCs from paired SV and ITA were cultured for experiments of Affymetrix microarrays and verification using FQ RT-PCR, while the database for annotation, visualization and integrated discovery bioinformatics resources (DAVID 2.0) was utilized for bioinformatics analysis of differential gene expression profile between SV VSMCs and ITA VSMCs. RNA of tunica media from SV and ITA segments were extracted for FQ RT-PCR to display differential expression of PLAT RESULTS: 54,613 probe sets were examined by gene microarray experiments. In SV VSMCs, 1,075 genes were up-regulated and 406 of them were higher than two-fold; 1,399 genes were down-regulated and 424 of them were lower than two-fold as compare with ITA VSMCs.14 ECM-related genes differentially expressed were verificated and listed as following: COL4A4, COL11A1, FN1, TNC, THBS, FBLN, MMP3, MMP9, TIMP3, WNT5A, SGCD were higher whereas COL14A1, ELN, PLAT lower in SV VSMCs than ITA VSMCs. In addition, PLAT was lower in tunica media from SV segments than ITA.
VSMCs from SV and ITA have distinct phenotypes characteristics. Both promoting and inhibiting migration ECM-related genes were higher in VSMCs from SV as compared with ITA, suggesting that VSMCs from SV have more potential migrating capability whereas less PLAT both in SV VSMCs and vascular tissue,implying that SV may prone to be restenosis after CABG. |
| doi_str_mv | 10.1186/1749-8090-8-155 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3700845</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A534718667</galeid><sourcerecordid>A534718667</sourcerecordid><originalsourceid>FETCH-LOGICAL-b541t-95c26c7c1246d803f6c7bc43b28c6c86df1a80fbfe9ad8a73561e78ec04820e53</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEoh9w5oYsceESasefuSC1qxaQirjA2XKcycZVYgc7WVF-PQ5blhaBxMn2zDOvZl5PUbwg-A0hSpwRyepS4RqXqiScPyqOD5HH9-5HxUlKNxgzTjF_WhxVVEoqsDwuvl9uPpYRBjNDi7bgAcG3KUJKLng0xdC5AZDzaGeSXQYTURpDmHs0LsnmjIVhSKiLYUT9MhqPkpl68GFJaAe5zPg2V88QvRnQ3IdorLPIxBy5fVY86cyQ4PndeVp8ubr8vHlfXn9692Fzfl02nJG5rLmthJWWVEy0CtMuPxrLaFMpK6wSbUeMwl3TQW1aZSTlgoBUYDFTFQZOT4u3e91paUZoLfg5mkFP0Y0m3upgnH6Y8a7X27DTVGKs2CpwsRdoXPiHwMOMDaNevder91rp_DNZ5PVdFzF8XSDNenRptc94yHZpwupKEKbq_0BpXeM8Jasz-uoP9CYsq9k_KcWJUlj8prZmAO18F3KbdhXV55wymTdJyEyd7SkbQ0oRusOEBOt12_4y08v7zh74X-tFfwCoDtF2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1398518806</pqid></control><display><type>article</type><title>ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery</title><source>SpringerOpen</source><source>MEDLINE</source><source>Springer Online Journals</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Zhu, Tian-xiang ; Lan, Bin ; Meng, Ling-ying ; Yang, Yan-long ; Li, Rui-xiong ; Li, En-min ; Zheng, Shao-yi ; Xu, Li-yan</creator><creatorcontrib>Zhu, Tian-xiang ; Lan, Bin ; Meng, Ling-ying ; Yang, Yan-long ; Li, Rui-xiong ; Li, En-min ; Zheng, Shao-yi ; Xu, Li-yan</creatorcontrib><description>Currently, Saphenous vein (SV) and internal thoracic artery (ITA) are still the most common graft materials in Coronary Artery Bypass Grafting (CABG) whereas SV graft have a lower long-term patency than ITA. Vascular smooth muscle cells (VSMCs) phenotype conversion, proliferation and migration may play a key role in mechanism of vein graft restenosis. To explore differential gene expression profile in VSMCs from SV and ITA will help to further elucidate the mechanism of VSMCs in vein graft restenosis after CABG and to provide new thread of gene therapy.
VSMCs from paired SV and ITA were cultured for experiments of Affymetrix microarrays and verification using FQ RT-PCR, while the database for annotation, visualization and integrated discovery bioinformatics resources (DAVID 2.0) was utilized for bioinformatics analysis of differential gene expression profile between SV VSMCs and ITA VSMCs. RNA of tunica media from SV and ITA segments were extracted for FQ RT-PCR to display differential expression of PLAT RESULTS: 54,613 probe sets were examined by gene microarray experiments. In SV VSMCs, 1,075 genes were up-regulated and 406 of them were higher than two-fold; 1,399 genes were down-regulated and 424 of them were lower than two-fold as compare with ITA VSMCs.14 ECM-related genes differentially expressed were verificated and listed as following: COL4A4, COL11A1, FN1, TNC, THBS, FBLN, MMP3, MMP9, TIMP3, WNT5A, SGCD were higher whereas COL14A1, ELN, PLAT lower in SV VSMCs than ITA VSMCs. In addition, PLAT was lower in tunica media from SV segments than ITA.
VSMCs from SV and ITA have distinct phenotypes characteristics. Both promoting and inhibiting migration ECM-related genes were higher in VSMCs from SV as compared with ITA, suggesting that VSMCs from SV have more potential migrating capability whereas less PLAT both in SV VSMCs and vascular tissue,implying that SV may prone to be restenosis after CABG.</description><identifier>ISSN: 1749-8090</identifier><identifier>EISSN: 1749-8090</identifier><identifier>DOI: 10.1186/1749-8090-8-155</identifier><identifier>PMID: 23773607</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Bioinformatics ; Cardiovascular disease ; Cell Movement ; Cell Proliferation ; Colleges & universities ; Computational Biology ; Coronary Artery Bypass ; Coronary vessels ; Electrophoresis, Agar Gel ; Extracellular Matrix - metabolism ; Gene expression ; Health aspects ; Humans ; Mammary Arteries - transplantation ; Medical research ; Microarray Analysis ; Muscle, Smooth, Vascular - cytology ; Myocytes, Smooth Muscle - metabolism ; Phenotype ; Real-Time Polymerase Chain Reaction ; Saphenous vein ; Saphenous Vein - transplantation ; Statistics, Nonparametric ; Transcriptome ; Vascular Patency ; Veins & arteries</subject><ispartof>Journal of cardiothoracic surgery, 2013-06, Vol.8 (1), p.155-155, Article 155</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Zhu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Zhu et al.; licensee BioMed Central Ltd. 2013 Zhu et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b541t-95c26c7c1246d803f6c7bc43b28c6c86df1a80fbfe9ad8a73561e78ec04820e53</citedby><cites>FETCH-LOGICAL-b541t-95c26c7c1246d803f6c7bc43b28c6c86df1a80fbfe9ad8a73561e78ec04820e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700845/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700845/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23773607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Tian-xiang</creatorcontrib><creatorcontrib>Lan, Bin</creatorcontrib><creatorcontrib>Meng, Ling-ying</creatorcontrib><creatorcontrib>Yang, Yan-long</creatorcontrib><creatorcontrib>Li, Rui-xiong</creatorcontrib><creatorcontrib>Li, En-min</creatorcontrib><creatorcontrib>Zheng, Shao-yi</creatorcontrib><creatorcontrib>Xu, Li-yan</creatorcontrib><title>ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery</title><title>Journal of cardiothoracic surgery</title><addtitle>J Cardiothorac Surg</addtitle><description>Currently, Saphenous vein (SV) and internal thoracic artery (ITA) are still the most common graft materials in Coronary Artery Bypass Grafting (CABG) whereas SV graft have a lower long-term patency than ITA. Vascular smooth muscle cells (VSMCs) phenotype conversion, proliferation and migration may play a key role in mechanism of vein graft restenosis. To explore differential gene expression profile in VSMCs from SV and ITA will help to further elucidate the mechanism of VSMCs in vein graft restenosis after CABG and to provide new thread of gene therapy.
VSMCs from paired SV and ITA were cultured for experiments of Affymetrix microarrays and verification using FQ RT-PCR, while the database for annotation, visualization and integrated discovery bioinformatics resources (DAVID 2.0) was utilized for bioinformatics analysis of differential gene expression profile between SV VSMCs and ITA VSMCs. RNA of tunica media from SV and ITA segments were extracted for FQ RT-PCR to display differential expression of PLAT RESULTS: 54,613 probe sets were examined by gene microarray experiments. In SV VSMCs, 1,075 genes were up-regulated and 406 of them were higher than two-fold; 1,399 genes were down-regulated and 424 of them were lower than two-fold as compare with ITA VSMCs.14 ECM-related genes differentially expressed were verificated and listed as following: COL4A4, COL11A1, FN1, TNC, THBS, FBLN, MMP3, MMP9, TIMP3, WNT5A, SGCD were higher whereas COL14A1, ELN, PLAT lower in SV VSMCs than ITA VSMCs. In addition, PLAT was lower in tunica media from SV segments than ITA.
VSMCs from SV and ITA have distinct phenotypes characteristics. Both promoting and inhibiting migration ECM-related genes were higher in VSMCs from SV as compared with ITA, suggesting that VSMCs from SV have more potential migrating capability whereas less PLAT both in SV VSMCs and vascular tissue,implying that SV may prone to be restenosis after CABG.</description><subject>Bioinformatics</subject><subject>Cardiovascular disease</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Colleges & universities</subject><subject>Computational Biology</subject><subject>Coronary Artery Bypass</subject><subject>Coronary vessels</subject><subject>Electrophoresis, Agar Gel</subject><subject>Extracellular Matrix - metabolism</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Mammary Arteries - transplantation</subject><subject>Medical research</subject><subject>Microarray Analysis</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Phenotype</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Saphenous vein</subject><subject>Saphenous Vein - transplantation</subject><subject>Statistics, Nonparametric</subject><subject>Transcriptome</subject><subject>Vascular Patency</subject><subject>Veins & arteries</subject><issn>1749-8090</issn><issn>1749-8090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEoh9w5oYsceESasefuSC1qxaQirjA2XKcycZVYgc7WVF-PQ5blhaBxMn2zDOvZl5PUbwg-A0hSpwRyepS4RqXqiScPyqOD5HH9-5HxUlKNxgzTjF_WhxVVEoqsDwuvl9uPpYRBjNDi7bgAcG3KUJKLng0xdC5AZDzaGeSXQYTURpDmHs0LsnmjIVhSKiLYUT9MhqPkpl68GFJaAe5zPg2V88QvRnQ3IdorLPIxBy5fVY86cyQ4PndeVp8ubr8vHlfXn9692Fzfl02nJG5rLmthJWWVEy0CtMuPxrLaFMpK6wSbUeMwl3TQW1aZSTlgoBUYDFTFQZOT4u3e91paUZoLfg5mkFP0Y0m3upgnH6Y8a7X27DTVGKs2CpwsRdoXPiHwMOMDaNevder91rp_DNZ5PVdFzF8XSDNenRptc94yHZpwupKEKbq_0BpXeM8Jasz-uoP9CYsq9k_KcWJUlj8prZmAO18F3KbdhXV55wymTdJyEyd7SkbQ0oRusOEBOt12_4y08v7zh74X-tFfwCoDtF2</recordid><startdate>20130618</startdate><enddate>20130618</enddate><creator>Zhu, Tian-xiang</creator><creator>Lan, Bin</creator><creator>Meng, Ling-ying</creator><creator>Yang, Yan-long</creator><creator>Li, Rui-xiong</creator><creator>Li, En-min</creator><creator>Zheng, Shao-yi</creator><creator>Xu, Li-yan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130618</creationdate><title>ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery</title><author>Zhu, Tian-xiang ; Lan, Bin ; Meng, Ling-ying ; Yang, Yan-long ; Li, Rui-xiong ; Li, En-min ; Zheng, Shao-yi ; Xu, Li-yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b541t-95c26c7c1246d803f6c7bc43b28c6c86df1a80fbfe9ad8a73561e78ec04820e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Bioinformatics</topic><topic>Cardiovascular disease</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Colleges & universities</topic><topic>Computational Biology</topic><topic>Coronary Artery Bypass</topic><topic>Coronary vessels</topic><topic>Electrophoresis, Agar Gel</topic><topic>Extracellular Matrix - metabolism</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Mammary Arteries - transplantation</topic><topic>Medical research</topic><topic>Microarray Analysis</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Phenotype</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Saphenous vein</topic><topic>Saphenous Vein - transplantation</topic><topic>Statistics, Nonparametric</topic><topic>Transcriptome</topic><topic>Vascular Patency</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Tian-xiang</creatorcontrib><creatorcontrib>Lan, Bin</creatorcontrib><creatorcontrib>Meng, Ling-ying</creatorcontrib><creatorcontrib>Yang, Yan-long</creatorcontrib><creatorcontrib>Li, Rui-xiong</creatorcontrib><creatorcontrib>Li, En-min</creatorcontrib><creatorcontrib>Zheng, Shao-yi</creatorcontrib><creatorcontrib>Xu, Li-yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiothoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Tian-xiang</au><au>Lan, Bin</au><au>Meng, Ling-ying</au><au>Yang, Yan-long</au><au>Li, Rui-xiong</au><au>Li, En-min</au><au>Zheng, Shao-yi</au><au>Xu, Li-yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery</atitle><jtitle>Journal of cardiothoracic surgery</jtitle><addtitle>J Cardiothorac Surg</addtitle><date>2013-06-18</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>155</spage><epage>155</epage><pages>155-155</pages><artnum>155</artnum><issn>1749-8090</issn><eissn>1749-8090</eissn><abstract>Currently, Saphenous vein (SV) and internal thoracic artery (ITA) are still the most common graft materials in Coronary Artery Bypass Grafting (CABG) whereas SV graft have a lower long-term patency than ITA. Vascular smooth muscle cells (VSMCs) phenotype conversion, proliferation and migration may play a key role in mechanism of vein graft restenosis. To explore differential gene expression profile in VSMCs from SV and ITA will help to further elucidate the mechanism of VSMCs in vein graft restenosis after CABG and to provide new thread of gene therapy.
VSMCs from paired SV and ITA were cultured for experiments of Affymetrix microarrays and verification using FQ RT-PCR, while the database for annotation, visualization and integrated discovery bioinformatics resources (DAVID 2.0) was utilized for bioinformatics analysis of differential gene expression profile between SV VSMCs and ITA VSMCs. RNA of tunica media from SV and ITA segments were extracted for FQ RT-PCR to display differential expression of PLAT RESULTS: 54,613 probe sets were examined by gene microarray experiments. In SV VSMCs, 1,075 genes were up-regulated and 406 of them were higher than two-fold; 1,399 genes were down-regulated and 424 of them were lower than two-fold as compare with ITA VSMCs.14 ECM-related genes differentially expressed were verificated and listed as following: COL4A4, COL11A1, FN1, TNC, THBS, FBLN, MMP3, MMP9, TIMP3, WNT5A, SGCD were higher whereas COL14A1, ELN, PLAT lower in SV VSMCs than ITA VSMCs. In addition, PLAT was lower in tunica media from SV segments than ITA.
VSMCs from SV and ITA have distinct phenotypes characteristics. Both promoting and inhibiting migration ECM-related genes were higher in VSMCs from SV as compared with ITA, suggesting that VSMCs from SV have more potential migrating capability whereas less PLAT both in SV VSMCs and vascular tissue,implying that SV may prone to be restenosis after CABG.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23773607</pmid><doi>10.1186/1749-8090-8-155</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1749-8090 |
| ispartof | Journal of cardiothoracic surgery, 2013-06, Vol.8 (1), p.155-155, Article 155 |
| issn | 1749-8090 1749-8090 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3700845 |
| source | SpringerOpen; MEDLINE; Springer Online Journals; PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Bioinformatics Cardiovascular disease Cell Movement Cell Proliferation Colleges & universities Computational Biology Coronary Artery Bypass Coronary vessels Electrophoresis, Agar Gel Extracellular Matrix - metabolism Gene expression Health aspects Humans Mammary Arteries - transplantation Medical research Microarray Analysis Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - metabolism Phenotype Real-Time Polymerase Chain Reaction Saphenous vein Saphenous Vein - transplantation Statistics, Nonparametric Transcriptome Vascular Patency Veins & arteries |
| title | ECM-related gene expression profile in vascular smooth muscle cells from human saphenous vein and internal thoracic artery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T15%3A36%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ECM-related%20gene%20expression%20profile%20in%20vascular%20smooth%20muscle%20cells%20from%20human%20saphenous%20vein%20and%20internal%20thoracic%20artery&rft.jtitle=Journal%20of%20cardiothoracic%20surgery&rft.au=Zhu,%20Tian-xiang&rft.date=2013-06-18&rft.volume=8&rft.issue=1&rft.spage=155&rft.epage=155&rft.pages=155-155&rft.artnum=155&rft.issn=1749-8090&rft.eissn=1749-8090&rft_id=info:doi/10.1186/1749-8090-8-155&rft_dat=%3Cgale_pubme%3EA534718667%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1398518806&rft_id=info:pmid/23773607&rft_galeid=A534718667&rfr_iscdi=true |