SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

B cell receptor (BCR) signaling pathway components represent promising treatment targets in diffuse large B cell lymphoma (DLBCL) and additional B cell tumors. BCR signaling activates spleen tyrosine kinase (SYK) and downstream pathways including PI3K/AKT and NF-κB. In previous studies, chemical SYK...

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Veröffentlicht in:	Cancer cell 2013-06, Vol.23 (6), p.826-838
Hauptverfasser:	Chen, Linfeng, Monti, Stefano, Juszczynski, Przemyslaw, Ouyang, Jing, Chapuy, Bjoern, Neuberg, Donna, Doench, John G., Bogusz, Agata M., Habermann, Thomas M., Dogan, Ahmet, Witzig, Thomas E., Kutok, Jeffery L., Rodig, Scott J., Golub, Todd, Shipp, Margaret A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Cell Line, Tumor Cell Proliferation Cholesterol - biosynthesis Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology Gene Expression Regulation, Neoplastic Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Lymphoma, Large B-Cell, Diffuse - enzymology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism NF-kappa B - metabolism Phosphatidylinositol 3-Kinase - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcr - metabolism Signal Transduction Syk Kinase
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