Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections
Abstract Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level o...
Gespeichert in:
| Veröffentlicht in: | Biomaterials 2009-05, Vol.30 (13), p.2552-2558 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2558 |
|---|---|
| container_issue | 13 |
| container_start_page | 2552 |
| container_title | Biomaterials |
| container_volume | 30 |
| creator | Li, Bingyun Jiang, Bingbing Boyce, Brandon M Lindsey, Brock A |
| description | Abstract Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo , and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach. |
| doi_str_mv | 10.1016/j.biomaterials.2009.01.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3699876</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961209000544</els_id><sourcerecordid>20406660</sourcerecordid><originalsourceid>FETCH-LOGICAL-c602t-ccc0cd7733ac48c77cf8758242eaea5d09c5dfb153ec61dda7d48885ce0f0e513</originalsourceid><addsrcrecordid>eNqNUk1v1DAQjRCIbgt_AVkcuCWMnTgfHCqhAqXSIg7A2fKOJ62XrB3sZKUVfx6HXUHhAidr5PfevJk3WfacQ8GB1y-3xcb6nZ4oWD3EQgB0BfACKvEgW_G2aXPZgXyYrYBXIu9qLs6y8xi3kOoEepyd8U5w2bWwyr5_mIfJDvpAgY1-OIw0TtYQc9r5iHoghl5P1t1GZh36MPrws2Q365wL1vvApjtiY6A9ucl6x3zPFntkbKIzQ3uLlOsYPdpk2SSZnnBBxifZoz4NQE9P70X25d3bz1fv8_XH65ur1-scaxBTjoiApmnKUmPVYtNg3zayFZUgTVoa6FCafsNlSVhzY3RjqrZtJRL0QJKXF9nlUXecN8kXJqNBD2oMdqfDQXlt1Z8_zt6pW79XZd11bVMngRcngeC_zRQntbMRaRi0Iz9HVZaNFMDLfwIFVFDXNSTgqyMQg48xUP_LDQe1hKy26n7IaglZAVcpv0R-dn-e39RTqgnw5gigtNW9paAiWnKYMglp98p4-399Lv-SwcG6JdavdKC49XNwC4erKBSoT8u5LdcGHQDIqip_AH-72VY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20406660</pqid></control><display><type>article</type><title>Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Li, Bingyun ; Jiang, Bingbing ; Boyce, Brandon M ; Lindsey, Brock A</creator><creatorcontrib>Li, Bingyun ; Jiang, Bingbing ; Boyce, Brandon M ; Lindsey, Brock A</creatorcontrib><description>Abstract Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo , and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2009.01.042</identifier><identifier>PMID: 19215980</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; Antimicrobial ; Biomedical Technology ; Bone ; Cytokine ; Dentistry ; Disease Models, Animal ; Drug delivery ; Fractures, Bone - pathology ; Humans ; Infection ; Infection Control ; Interleukin-12 - chemistry ; Interleukin-12 - pharmacology ; Microscopy, Electron, Scanning ; Nanostructures - chemistry ; Peptides - chemistry ; Rats ; Static Electricity ; Surface modification</subject><ispartof>Biomaterials, 2009-05, Vol.30 (13), p.2552-2558</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-ccc0cd7733ac48c77cf8758242eaea5d09c5dfb153ec61dda7d48885ce0f0e513</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2009.01.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19215980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Bingyun</creatorcontrib><creatorcontrib>Jiang, Bingbing</creatorcontrib><creatorcontrib>Boyce, Brandon M</creatorcontrib><creatorcontrib>Lindsey, Brock A</creatorcontrib><title>Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo , and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Antimicrobial</subject><subject>Biomedical Technology</subject><subject>Bone</subject><subject>Cytokine</subject><subject>Dentistry</subject><subject>Disease Models, Animal</subject><subject>Drug delivery</subject><subject>Fractures, Bone - pathology</subject><subject>Humans</subject><subject>Infection</subject><subject>Infection Control</subject><subject>Interleukin-12 - chemistry</subject><subject>Interleukin-12 - pharmacology</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanostructures - chemistry</subject><subject>Peptides - chemistry</subject><subject>Rats</subject><subject>Static Electricity</subject><subject>Surface modification</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIbgt_AVkcuCWMnTgfHCqhAqXSIg7A2fKOJ62XrB3sZKUVfx6HXUHhAidr5PfevJk3WfacQ8GB1y-3xcb6nZ4oWD3EQgB0BfACKvEgW_G2aXPZgXyYrYBXIu9qLs6y8xi3kOoEepyd8U5w2bWwyr5_mIfJDvpAgY1-OIw0TtYQc9r5iHoghl5P1t1GZh36MPrws2Q365wL1vvApjtiY6A9ucl6x3zPFntkbKIzQ3uLlOsYPdpk2SSZnnBBxifZoz4NQE9P70X25d3bz1fv8_XH65ur1-scaxBTjoiApmnKUmPVYtNg3zayFZUgTVoa6FCafsNlSVhzY3RjqrZtJRL0QJKXF9nlUXecN8kXJqNBD2oMdqfDQXlt1Z8_zt6pW79XZd11bVMngRcngeC_zRQntbMRaRi0Iz9HVZaNFMDLfwIFVFDXNSTgqyMQg48xUP_LDQe1hKy26n7IaglZAVcpv0R-dn-e39RTqgnw5gigtNW9paAiWnKYMglp98p4-399Lv-SwcG6JdavdKC49XNwC4erKBSoT8u5LdcGHQDIqip_AH-72VY</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Li, Bingyun</creator><creator>Jiang, Bingbing</creator><creator>Boyce, Brandon M</creator><creator>Lindsey, Brock A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections</title><author>Li, Bingyun ; Jiang, Bingbing ; Boyce, Brandon M ; Lindsey, Brock A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-ccc0cd7733ac48c77cf8758242eaea5d09c5dfb153ec61dda7d48885ce0f0e513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Antimicrobial</topic><topic>Biomedical Technology</topic><topic>Bone</topic><topic>Cytokine</topic><topic>Dentistry</topic><topic>Disease Models, Animal</topic><topic>Drug delivery</topic><topic>Fractures, Bone - pathology</topic><topic>Humans</topic><topic>Infection</topic><topic>Infection Control</topic><topic>Interleukin-12 - chemistry</topic><topic>Interleukin-12 - pharmacology</topic><topic>Microscopy, Electron, Scanning</topic><topic>Nanostructures - chemistry</topic><topic>Peptides - chemistry</topic><topic>Rats</topic><topic>Static Electricity</topic><topic>Surface modification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Bingyun</creatorcontrib><creatorcontrib>Jiang, Bingbing</creatorcontrib><creatorcontrib>Boyce, Brandon M</creatorcontrib><creatorcontrib>Lindsey, Brock A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Bingyun</au><au>Jiang, Bingbing</au><au>Boyce, Brandon M</au><au>Lindsey, Brock A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>30</volume><issue>13</issue><spage>2552</spage><epage>2558</epage><pages>2552-2558</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo , and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19215980</pmid><doi>10.1016/j.biomaterials.2009.01.042</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2009-05, Vol.30 (13), p.2552-2558 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3699876 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Advanced Basic Science Animals Antimicrobial Biomedical Technology Bone Cytokine Dentistry Disease Models, Animal Drug delivery Fractures, Bone - pathology Humans Infection Infection Control Interleukin-12 - chemistry Interleukin-12 - pharmacology Microscopy, Electron, Scanning Nanostructures - chemistry Peptides - chemistry Rats Static Electricity Surface modification |
| title | Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T11%3A12%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multilayer%20polypeptide%20nanoscale%20coatings%20incorporating%20IL-12%20for%20the%20prevention%20of%20biomedical%20device-associated%20infections&rft.jtitle=Biomaterials&rft.au=Li,%20Bingyun&rft.date=2009-05-01&rft.volume=30&rft.issue=13&rft.spage=2552&rft.epage=2558&rft.pages=2552-2558&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/j.biomaterials.2009.01.042&rft_dat=%3Cproquest_pubme%3E20406660%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20406660&rft_id=info:pmid/19215980&rft_els_id=S0142961209000544&rfr_iscdi=true |