Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection?
Since the routine clinical use of the sentinel lymph node (SLN) procedure, questions have been raised concerning an increase in the overall percentage of node-positive patients. The goal of our study was to compare the sensitivity of the SLN procedure and the axillary lymph node dissection (ALND) fo...
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| creator | Smeets, Ann Yoshihara, Emi Laenen, Annouschka Reynders, Anneleen Soens, Julie Wildiers, Hans Paridaens, Robert Van Ongeval, Chantal Floris, Giuseppe Neven, Patrick Christiaens, Marie-Rose |
| description | Since the routine clinical use of the sentinel lymph node (SLN) procedure, questions have been raised concerning an increase in the overall percentage of node-positive patients. The goal of our study was to compare the sensitivity of the SLN procedure and the axillary lymph node dissection (ALND) for the identification of positive lymph nodes in breast cancer.
The incidence of axillary node metastasis in SLNB and ALND specimens from patients undergoing operative treatment of a primary breast carcinoma was compared retrospectively.
Logistic regression models were used to analyze the effect of various predictors on the presence of positive lymph nodes. We constructed a multivariate model including the procedure and these predictors that have shown to be related to lymph node involvement in univariate analysis. The probability of finding positive lymph nodes was thus calculated in both groups correcting for relevant predictors of lymph node involvement.
The SLNB group included 830 patients, the ALND group 320. In a multivariate analysis, adjusting for the number of foci, tumor location in the breast, tumor size, LVI, ER, PR, tumor grade and histological subtype, the probability of finding positive lymph nodes was higher with SLNB procedure than with an ALND. However, this difference was not statistically significant (OR 0.7635; CI 0.5334-1.0930, p 0.1404).
For comparable tumors, SLNB procedure is at least as sensitive as ALND for detecting positive lymph nodes. |
| doi_str_mv | 10.1186/2193-1801-2-275 |
| format | Article |
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The incidence of axillary node metastasis in SLNB and ALND specimens from patients undergoing operative treatment of a primary breast carcinoma was compared retrospectively.
Logistic regression models were used to analyze the effect of various predictors on the presence of positive lymph nodes. We constructed a multivariate model including the procedure and these predictors that have shown to be related to lymph node involvement in univariate analysis. The probability of finding positive lymph nodes was thus calculated in both groups correcting for relevant predictors of lymph node involvement.
The SLNB group included 830 patients, the ALND group 320. In a multivariate analysis, adjusting for the number of foci, tumor location in the breast, tumor size, LVI, ER, PR, tumor grade and histological subtype, the probability of finding positive lymph nodes was higher with SLNB procedure than with an ALND. However, this difference was not statistically significant (OR 0.7635; CI 0.5334-1.0930, p 0.1404).
For comparable tumors, SLNB procedure is at least as sensitive as ALND for detecting positive lymph nodes.</description><identifier>ISSN: 2193-1801</identifier><identifier>EISSN: 2193-1801</identifier><identifier>DOI: 10.1186/2193-1801-2-275</identifier><identifier>PMID: 23961380</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Humanities and Social Sciences ; multidisciplinary ; Oncology ; Science ; Science (multidisciplinary)</subject><ispartof>SpringerPlus, 2013-06, Vol.2 (1), p.275-275, Article 275</ispartof><rights>Smeets et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>SpringerPlus is a copyright of Springer, 2013.</rights><rights>Smeets et al.; licensee Springer. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b521t-e9a74e5c1a1330234957d05ffa12e7a82fa3d86e4371853fb450214ab1408d233</citedby><cites>FETCH-LOGICAL-b521t-e9a74e5c1a1330234957d05ffa12e7a82fa3d86e4371853fb450214ab1408d233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699711/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699711/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23961380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smeets, Ann</creatorcontrib><creatorcontrib>Yoshihara, Emi</creatorcontrib><creatorcontrib>Laenen, Annouschka</creatorcontrib><creatorcontrib>Reynders, Anneleen</creatorcontrib><creatorcontrib>Soens, Julie</creatorcontrib><creatorcontrib>Wildiers, Hans</creatorcontrib><creatorcontrib>Paridaens, Robert</creatorcontrib><creatorcontrib>Van Ongeval, Chantal</creatorcontrib><creatorcontrib>Floris, Giuseppe</creatorcontrib><creatorcontrib>Neven, Patrick</creatorcontrib><creatorcontrib>Christiaens, Marie-Rose</creatorcontrib><title>Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection?</title><title>SpringerPlus</title><addtitle>SpringerPlus</addtitle><addtitle>Springerplus</addtitle><description>Since the routine clinical use of the sentinel lymph node (SLN) procedure, questions have been raised concerning an increase in the overall percentage of node-positive patients. The goal of our study was to compare the sensitivity of the SLN procedure and the axillary lymph node dissection (ALND) for the identification of positive lymph nodes in breast cancer.
The incidence of axillary node metastasis in SLNB and ALND specimens from patients undergoing operative treatment of a primary breast carcinoma was compared retrospectively.
Logistic regression models were used to analyze the effect of various predictors on the presence of positive lymph nodes. We constructed a multivariate model including the procedure and these predictors that have shown to be related to lymph node involvement in univariate analysis. The probability of finding positive lymph nodes was thus calculated in both groups correcting for relevant predictors of lymph node involvement.
The SLNB group included 830 patients, the ALND group 320. In a multivariate analysis, adjusting for the number of foci, tumor location in the breast, tumor size, LVI, ER, PR, tumor grade and histological subtype, the probability of finding positive lymph nodes was higher with SLNB procedure than with an ALND. However, this difference was not statistically significant (OR 0.7635; CI 0.5334-1.0930, p 0.1404).
For comparable tumors, SLNB procedure is at least as sensitive as ALND for detecting positive lymph nodes.</description><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Oncology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2193-1801</issn><issn>2193-1801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhi0EolXpmRuyxIVLqMdOYucCgoqPSpW4wNlynEnXVWIHO1t1fwr_Fmd3WbaI-mLL884zr2dMyEtgbwFUfcGhEQUoBgUvuKyekNPDzdOj8wk5T-mW5VVLKCV7Tk64aGoQip2SX1eJziukCf3sPA502IzTivrQIW1dmNKGjiFu48nN7g5pH-I2w3VLSu-smV3wNPR0CnvJX0aiztM2okkztcZbXHKN3wLMvRsGEzfHJTuXEtoF-P4FedabIeH5fj8jPz5_-n75tbj-9uXq8sN10VYc5gIbI0usLBgQgnFRNpXsWNX3BjhKo3hvRKdqLIUEVYm-LSvGoTQtlEx1XIgz8m7HndbtiJ3Nr4pm0FN0Yzang3H6YcS7lb4Jd1rUTSMBMuDjDpD79QjgYcSGUS_T0ct0NNd5dhnyZu8ihp9rTLMeXbKYG-QxrJOGktcyO1cqS1__I70N6-hzjzKwznOFrMuqi53KxpBSxP5gCJhevs9_LLw6bsRB_-ezZAHbCVIO-RuMR4UfYf4G_1PSCw</recordid><startdate>20130623</startdate><enddate>20130623</enddate><creator>Smeets, Ann</creator><creator>Yoshihara, Emi</creator><creator>Laenen, Annouschka</creator><creator>Reynders, Anneleen</creator><creator>Soens, Julie</creator><creator>Wildiers, Hans</creator><creator>Paridaens, Robert</creator><creator>Van Ongeval, Chantal</creator><creator>Floris, Giuseppe</creator><creator>Neven, Patrick</creator><creator>Christiaens, Marie-Rose</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>BioMed Central Ltd</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FK</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>KB.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130623</creationdate><title>Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection?</title><author>Smeets, Ann ; Yoshihara, Emi ; Laenen, Annouschka ; Reynders, Anneleen ; Soens, Julie ; Wildiers, Hans ; Paridaens, Robert ; Van Ongeval, Chantal ; Floris, Giuseppe ; Neven, Patrick ; Christiaens, Marie-Rose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b521t-e9a74e5c1a1330234957d05ffa12e7a82fa3d86e4371853fb450214ab1408d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Humanities and Social Sciences</topic><topic>multidisciplinary</topic><topic>Oncology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smeets, Ann</creatorcontrib><creatorcontrib>Yoshihara, Emi</creatorcontrib><creatorcontrib>Laenen, Annouschka</creatorcontrib><creatorcontrib>Reynders, Anneleen</creatorcontrib><creatorcontrib>Soens, Julie</creatorcontrib><creatorcontrib>Wildiers, Hans</creatorcontrib><creatorcontrib>Paridaens, Robert</creatorcontrib><creatorcontrib>Van Ongeval, Chantal</creatorcontrib><creatorcontrib>Floris, Giuseppe</creatorcontrib><creatorcontrib>Neven, Patrick</creatorcontrib><creatorcontrib>Christiaens, Marie-Rose</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>SpringerPlus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smeets, Ann</au><au>Yoshihara, Emi</au><au>Laenen, Annouschka</au><au>Reynders, Anneleen</au><au>Soens, Julie</au><au>Wildiers, Hans</au><au>Paridaens, Robert</au><au>Van Ongeval, Chantal</au><au>Floris, Giuseppe</au><au>Neven, Patrick</au><au>Christiaens, Marie-Rose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection?</atitle><jtitle>SpringerPlus</jtitle><stitle>SpringerPlus</stitle><addtitle>Springerplus</addtitle><date>2013-06-23</date><risdate>2013</risdate><volume>2</volume><issue>1</issue><spage>275</spage><epage>275</epage><pages>275-275</pages><artnum>275</artnum><issn>2193-1801</issn><eissn>2193-1801</eissn><abstract>Since the routine clinical use of the sentinel lymph node (SLN) procedure, questions have been raised concerning an increase in the overall percentage of node-positive patients. The goal of our study was to compare the sensitivity of the SLN procedure and the axillary lymph node dissection (ALND) for the identification of positive lymph nodes in breast cancer.
The incidence of axillary node metastasis in SLNB and ALND specimens from patients undergoing operative treatment of a primary breast carcinoma was compared retrospectively.
Logistic regression models were used to analyze the effect of various predictors on the presence of positive lymph nodes. We constructed a multivariate model including the procedure and these predictors that have shown to be related to lymph node involvement in univariate analysis. The probability of finding positive lymph nodes was thus calculated in both groups correcting for relevant predictors of lymph node involvement.
The SLNB group included 830 patients, the ALND group 320. In a multivariate analysis, adjusting for the number of foci, tumor location in the breast, tumor size, LVI, ER, PR, tumor grade and histological subtype, the probability of finding positive lymph nodes was higher with SLNB procedure than with an ALND. However, this difference was not statistically significant (OR 0.7635; CI 0.5334-1.0930, p 0.1404).
For comparable tumors, SLNB procedure is at least as sensitive as ALND for detecting positive lymph nodes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>23961380</pmid><doi>10.1186/2193-1801-2-275</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Humanities and Social Sciences multidisciplinary Oncology Science Science (multidisciplinary) |
| title | Is the sentinel lymph node biopsy more sensitive for the identification of positive lymph nodes in breast cancer than the axillary lymph node dissection? |
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