PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for the degradation of poly(ADP-ribose). PARG dysfunction sensitizes cells to alkylating agents and induces cell death; however, the details of this effect have not been fully elucidated. Here, we investigated the mechanism by...

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Veröffentlicht in:	Cell death & disease 2013-06, Vol.4 (6), p.e656-e656
Hauptverfasser:	Shirai, H, Poetsch, A R, Gunji, A, Maeda, D, Fujimori, H, Fujihara, H, Yoshida, T, Ogino, H, Masutani, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427/2122 631/67 631/80/82 Alkylation Animals Antibodies Antineoplastic Agents, Alkylating - pharmacology Apoptosis Biochemistry Biomedical and Life Sciences Caspases - metabolism Cell Biology Cell Culture Cell Line Cell Line, Tumor DNA Adducts - metabolism DNA Breaks, Double-Stranded DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Gene Knockout Techniques Glycoside Hydrolases - deficiency Glycoside Hydrolases - genetics Humans Immunology Life Sciences Membrane Potential, Mitochondrial Methyl Methanesulfonate - pharmacology Mice Mutagens - pharmacology Original original-article Poly Adenosine Diphosphate Ribose - metabolism S Phase Tumor Suppressor Protein p53 - metabolism
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