Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation

Risk alleles for complex diseases are widely spread throughout human populations. However, little is known about the geographic distribution and frequencies of risk alleles, which may contribute to differences in disease susceptibility and prevalence among populations. Here, we focus on Crohn's...

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Veröffentlicht in:	Molecular biology and evolution 2012-06, Vol.29 (6), p.1569-1585
Hauptverfasser:	Nakagome, Shigeki, Mano, Shuhei, Kozlowski, Lukasz, Bujnicki, Janusz M, Shibata, Hiroki, Fukumaki, Yasuaki, Kidd, Judith R, Kidd, Kenneth K, Kawamura, Shoji, Oota, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Amino acids Crohn Disease - genetics Crohn's disease Data processing Diploids Evolution Gene Frequency Gene loci genealogy Genetic Predisposition to Disease Genomics Genotyping Techniques Geographical distribution Haplotypes Health risks Human populations Humans Linkage analysis Models, Genetic Models, Molecular Molecular biology Molecular structure Mutation Natural selection Negative selection NOD2 protein Nod2 Signaling Adaptor Protein - chemistry Nod2 Signaling Adaptor Protein - genetics Phylogeny Polymorphism, Single Nucleotide Population genetics Population growth Protein Structure, Secondary Protein Structure, Tertiary Proteins Risk Factors Roots Selection, Genetic Sequence Analysis, DNA
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