Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery
Objective Spontaneous labor at term involves the activation of placental corticotropin-releasing hormone and the fetal adrenal axis, but the basis for extreme preterm labor is unknown. Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm la...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2012-03, Vol.206 (3), p.236.e1-236.e8 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 206 |
| creator | Trivedi, Sunita, MD Joachim, Maria, BS McElrath, Thomas, MD, PhD Kliman, Harvey J., MD, PhD Allred, Elizabeth N., MS Fichorova, Raina N., MD, PhD Onderdonk, Andrew, PhD Heitor, Fernanda, MD Chaychi, Leila, MD Leviton, Alan, MD Majzoub, Joseph A., MD |
| description | Objective Spontaneous labor at term involves the activation of placental corticotropin-releasing hormone and the fetal adrenal axis, but the basis for extreme preterm labor is unknown. Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor. Study Design One thousand five hundred six mothers delivering at less than 28 weeks' gestation were enrolled. Each mother/infant pair was assigned to the category that described the primary reason for hospitalization. Observers who had no knowledge of patient categorization assessed placenta microbiology, histology, and corticotropin-releasing hormone expression. These were correlated with the primary reason for hospitalization. Results Among infants delivered at less than 28 weeks' gestation, spontaneous (vs induced) delivery was associated with less placental corticotropin-releasing hormone expression and more frequent signs of placental inflammation and infection. Conclusion Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth. |
| doi_str_mv | 10.1016/j.ajog.2011.12.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3696892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937811023787</els_id><sourcerecordid>926155754</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-21b86983ccff4043d05490e7fba3f371bc67593aa0707d0758bfae9b31a1c3da3</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEokvhD3BAuSAuJPgjsWMJVUIVBaRKHICzNXEmrRcnXmxnYf89jnYpHwdOY2ued2bsd4riKSU1JVS82taw9Tc1I5TWlNWENPeKDSVKVqIT3f1iQwhhleKyOysexbhdr0yxh8UZY0w0omWbAq8wgat2DgzO-VTaeXQwTZCsn1-W_ZLK2acShoBzzoJJdn_K2VhCjN5YSDiU3226LfFHCjhhuQuYMEzlgM7uMRweFw9GcBGfnOJ58eXq7efL99X1x3cfLt9cV6blKlWM9p1QHTdmHBvS8IG0jSIoxx74yCXtjZCt4gBEEjkQ2Xb9CKh6ToEaPgA_Ly6OdXdLP-GwPimA07tgJwgH7cHqvzOzvdU3fq-5UKJTLBd4cSoQ_LcFY9KTjQadgxn9ErVigratbJtMsiNpgo8x4HjXhRK92qO3erVHr_ZoynS2J4ue_TnfneSXHxl4fgIgGnBjgNnY-JtrRcOJ5Jl7feQw_-beYtDRWJwNDjagSXrw9v9zXPwjN87ONnf8igeMW7-E7HbUVMcs0J_WzVn3iFLCcpD8J__OxYY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>926155754</pqid></control><display><type>article</type><title>Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Trivedi, Sunita, MD ; Joachim, Maria, BS ; McElrath, Thomas, MD, PhD ; Kliman, Harvey J., MD, PhD ; Allred, Elizabeth N., MS ; Fichorova, Raina N., MD, PhD ; Onderdonk, Andrew, PhD ; Heitor, Fernanda, MD ; Chaychi, Leila, MD ; Leviton, Alan, MD ; Majzoub, Joseph A., MD</creator><creatorcontrib>Trivedi, Sunita, MD ; Joachim, Maria, BS ; McElrath, Thomas, MD, PhD ; Kliman, Harvey J., MD, PhD ; Allred, Elizabeth N., MS ; Fichorova, Raina N., MD, PhD ; Onderdonk, Andrew, PhD ; Heitor, Fernanda, MD ; Chaychi, Leila, MD ; Leviton, Alan, MD ; Majzoub, Joseph A., MD ; Extremely Low Gestational Age Newborns (ELGAN) study investigators</creatorcontrib><description>Objective Spontaneous labor at term involves the activation of placental corticotropin-releasing hormone and the fetal adrenal axis, but the basis for extreme preterm labor is unknown. Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor. Study Design One thousand five hundred six mothers delivering at less than 28 weeks' gestation were enrolled. Each mother/infant pair was assigned to the category that described the primary reason for hospitalization. Observers who had no knowledge of patient categorization assessed placenta microbiology, histology, and corticotropin-releasing hormone expression. These were correlated with the primary reason for hospitalization. Results Among infants delivered at less than 28 weeks' gestation, spontaneous (vs induced) delivery was associated with less placental corticotropin-releasing hormone expression and more frequent signs of placental inflammation and infection. Conclusion Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2011.12.004</identifier><identifier>PMID: 22264652</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adrenal Glands - metabolism ; Biological and medical sciences ; Chorioamnionitis - microbiology ; Cohort Studies ; corticotropin-releasing hormone ; Corticotropin-Releasing Hormone - analysis ; Cytokines - blood ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; infection ; inflammation ; Male ; Medical sciences ; Multicenter Studies as Topic ; Obstetrics and Gynecology ; Placenta - chemistry ; Placenta - cytology ; Placenta - microbiology ; Pregnancy ; Pregnancy Complications, Infectious - microbiology ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; Premature Birth - microbiology ; preterm delivery</subject><ispartof>American journal of obstetrics and gynecology, 2012-03, Vol.206 (3), p.236.e1-236.e8</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012. Published by Mosby, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-21b86983ccff4043d05490e7fba3f371bc67593aa0707d0758bfae9b31a1c3da3</citedby><cites>FETCH-LOGICAL-c539t-21b86983ccff4043d05490e7fba3f371bc67593aa0707d0758bfae9b31a1c3da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2011.12.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25643073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22264652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trivedi, Sunita, MD</creatorcontrib><creatorcontrib>Joachim, Maria, BS</creatorcontrib><creatorcontrib>McElrath, Thomas, MD, PhD</creatorcontrib><creatorcontrib>Kliman, Harvey J., MD, PhD</creatorcontrib><creatorcontrib>Allred, Elizabeth N., MS</creatorcontrib><creatorcontrib>Fichorova, Raina N., MD, PhD</creatorcontrib><creatorcontrib>Onderdonk, Andrew, PhD</creatorcontrib><creatorcontrib>Heitor, Fernanda, MD</creatorcontrib><creatorcontrib>Chaychi, Leila, MD</creatorcontrib><creatorcontrib>Leviton, Alan, MD</creatorcontrib><creatorcontrib>Majzoub, Joseph A., MD</creatorcontrib><creatorcontrib>Extremely Low Gestational Age Newborns (ELGAN) study investigators</creatorcontrib><title>Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective Spontaneous labor at term involves the activation of placental corticotropin-releasing hormone and the fetal adrenal axis, but the basis for extreme preterm labor is unknown. Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor. Study Design One thousand five hundred six mothers delivering at less than 28 weeks' gestation were enrolled. Each mother/infant pair was assigned to the category that described the primary reason for hospitalization. Observers who had no knowledge of patient categorization assessed placenta microbiology, histology, and corticotropin-releasing hormone expression. These were correlated with the primary reason for hospitalization. Results Among infants delivered at less than 28 weeks' gestation, spontaneous (vs induced) delivery was associated with less placental corticotropin-releasing hormone expression and more frequent signs of placental inflammation and infection. Conclusion Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth.</description><subject>Adrenal Glands - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chorioamnionitis - microbiology</subject><subject>Cohort Studies</subject><subject>corticotropin-releasing hormone</subject><subject>Corticotropin-Releasing Hormone - analysis</subject><subject>Cytokines - blood</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>infection</subject><subject>inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multicenter Studies as Topic</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta - chemistry</subject><subject>Placenta - cytology</subject><subject>Placenta - microbiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - microbiology</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature Birth - microbiology</subject><subject>preterm delivery</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1v1DAQhiMEokvhD3BAuSAuJPgjsWMJVUIVBaRKHICzNXEmrRcnXmxnYf89jnYpHwdOY2ued2bsd4riKSU1JVS82taw9Tc1I5TWlNWENPeKDSVKVqIT3f1iQwhhleKyOysexbhdr0yxh8UZY0w0omWbAq8wgat2DgzO-VTaeXQwTZCsn1-W_ZLK2acShoBzzoJJdn_K2VhCjN5YSDiU3226LfFHCjhhuQuYMEzlgM7uMRweFw9GcBGfnOJ58eXq7efL99X1x3cfLt9cV6blKlWM9p1QHTdmHBvS8IG0jSIoxx74yCXtjZCt4gBEEjkQ2Xb9CKh6ToEaPgA_Ly6OdXdLP-GwPimA07tgJwgH7cHqvzOzvdU3fq-5UKJTLBd4cSoQ_LcFY9KTjQadgxn9ErVigratbJtMsiNpgo8x4HjXhRK92qO3erVHr_ZoynS2J4ue_TnfneSXHxl4fgIgGnBjgNnY-JtrRcOJ5Jl7feQw_-beYtDRWJwNDjagSXrw9v9zXPwjN87ONnf8igeMW7-E7HbUVMcs0J_WzVn3iFLCcpD8J__OxYY</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Trivedi, Sunita, MD</creator><creator>Joachim, Maria, BS</creator><creator>McElrath, Thomas, MD, PhD</creator><creator>Kliman, Harvey J., MD, PhD</creator><creator>Allred, Elizabeth N., MS</creator><creator>Fichorova, Raina N., MD, PhD</creator><creator>Onderdonk, Andrew, PhD</creator><creator>Heitor, Fernanda, MD</creator><creator>Chaychi, Leila, MD</creator><creator>Leviton, Alan, MD</creator><creator>Majzoub, Joseph A., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery</title><author>Trivedi, Sunita, MD ; Joachim, Maria, BS ; McElrath, Thomas, MD, PhD ; Kliman, Harvey J., MD, PhD ; Allred, Elizabeth N., MS ; Fichorova, Raina N., MD, PhD ; Onderdonk, Andrew, PhD ; Heitor, Fernanda, MD ; Chaychi, Leila, MD ; Leviton, Alan, MD ; Majzoub, Joseph A., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-21b86983ccff4043d05490e7fba3f371bc67593aa0707d0758bfae9b31a1c3da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adrenal Glands - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chorioamnionitis - microbiology</topic><topic>Cohort Studies</topic><topic>corticotropin-releasing hormone</topic><topic>Corticotropin-Releasing Hormone - analysis</topic><topic>Cytokines - blood</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>infection</topic><topic>inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multicenter Studies as Topic</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta - chemistry</topic><topic>Placenta - cytology</topic><topic>Placenta - microbiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - microbiology</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature Birth - microbiology</topic><topic>preterm delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trivedi, Sunita, MD</creatorcontrib><creatorcontrib>Joachim, Maria, BS</creatorcontrib><creatorcontrib>McElrath, Thomas, MD, PhD</creatorcontrib><creatorcontrib>Kliman, Harvey J., MD, PhD</creatorcontrib><creatorcontrib>Allred, Elizabeth N., MS</creatorcontrib><creatorcontrib>Fichorova, Raina N., MD, PhD</creatorcontrib><creatorcontrib>Onderdonk, Andrew, PhD</creatorcontrib><creatorcontrib>Heitor, Fernanda, MD</creatorcontrib><creatorcontrib>Chaychi, Leila, MD</creatorcontrib><creatorcontrib>Leviton, Alan, MD</creatorcontrib><creatorcontrib>Majzoub, Joseph A., MD</creatorcontrib><creatorcontrib>Extremely Low Gestational Age Newborns (ELGAN) study investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trivedi, Sunita, MD</au><au>Joachim, Maria, BS</au><au>McElrath, Thomas, MD, PhD</au><au>Kliman, Harvey J., MD, PhD</au><au>Allred, Elizabeth N., MS</au><au>Fichorova, Raina N., MD, PhD</au><au>Onderdonk, Andrew, PhD</au><au>Heitor, Fernanda, MD</au><au>Chaychi, Leila, MD</au><au>Leviton, Alan, MD</au><au>Majzoub, Joseph A., MD</au><aucorp>Extremely Low Gestational Age Newborns (ELGAN) study investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>206</volume><issue>3</issue><spage>236.e1</spage><epage>236.e8</epage><pages>236.e1-236.e8</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective Spontaneous labor at term involves the activation of placental corticotropin-releasing hormone and the fetal adrenal axis, but the basis for extreme preterm labor is unknown. Our objective was to determine whether placental corticotropin-releasing hormone is activated in extreme preterm labor. Study Design One thousand five hundred six mothers delivering at less than 28 weeks' gestation were enrolled. Each mother/infant pair was assigned to the category that described the primary reason for hospitalization. Observers who had no knowledge of patient categorization assessed placenta microbiology, histology, and corticotropin-releasing hormone expression. These were correlated with the primary reason for hospitalization. Results Among infants delivered at less than 28 weeks' gestation, spontaneous (vs induced) delivery was associated with less placental corticotropin-releasing hormone expression and more frequent signs of placental inflammation and infection. Conclusion Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22264652</pmid><doi>10.1016/j.ajog.2011.12.004</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adrenal Glands - metabolism Biological and medical sciences Chorioamnionitis - microbiology Cohort Studies corticotropin-releasing hormone Corticotropin-Releasing Hormone - analysis Cytokines - blood Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Infant, Newborn infection inflammation Male Medical sciences Multicenter Studies as Topic Obstetrics and Gynecology Placenta - chemistry Placenta - cytology Placenta - microbiology Pregnancy Pregnancy Complications, Infectious - microbiology Pregnancy Outcome Pregnancy. Fetus. Placenta Premature Birth - microbiology preterm delivery |
| title | Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery |
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