The Arrestin-selective Angiotensin AT1 Receptor Agonist [Sar1,Ile4,Ile8]-AngII Negatively Regulates Bradykinin B2 Receptor Signaling via AT1-B2 Receptor Heterodimers

The renin-angiotensin and kallikrein-kinin systems are key regulators of vascular tone and inflammation. Angiotensin II, the principal effector of the renin-angiotensin system, promotes vasoconstriction by activating angiotensin AT1 receptors. The opposing effects of the kallikrein-kinin system are...

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Veröffentlicht in:	The Journal of biological chemistry 2013-06, Vol.288 (26), p.18872-18884
Hauptverfasser:	Wilson, Parker C., Lee, Mi-Hye, Appleton, Kathryn M., El-Shewy, Hesham M., Morinelli, Thomas A., Peterson, Yuri K., Luttrell, Louis M., Jaffa, Ayad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Angiotensin Angiotensin II - analogs & derivatives Angiotensin II - pharmacology Animals Aorta - cytology Arrestin Arrestins - metabolism Biased Agonism Bradykinin Calcium - metabolism Dimerization Dose-Response Relationship, Drug G Protein-coupled Receptors (GPCR) G Proteins GTP-Binding Proteins - metabolism HEK293 Cells Hemodynamics Heterodimerization Humans Kallikreins - metabolism Ligands Losartan - pharmacology Myocytes, Smooth Muscle - cytology Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - agonists Receptor, Angiotensin, Type 1 - metabolism Receptor, Bradykinin B2 - metabolism Sequestration Signal Transduction
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