CD4⁺ follicular helper T cell infiltration predicts breast cancer survival

CD4⁺ T cells are critical regulators of immune responses, but their functional role in human breast cancer is relatively unknown. The goal of this study was to produce an image of CD4⁺ T cells infiltrating breast tumors using limited ex vivo manipulation to better understand the in vivo differences...

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Veröffentlicht in:	The Journal of clinical investigation 2013-07, Vol.123 (7), p.2873-2892
Hauptverfasser:	Gu-Trantien, Chunyan, Loi, Sherene, Garaud, Soizic, Equeter, Carole, Libin, Myriam, de Wind, Alexandre, Ravoet, Marie, Le Buanec, Hélène, Sibille, Catherine, Manfouo-Foutsop, Germain, Veys, Isabelle, Haibe-Kains, Benjamin, Singhal, Sandeep K, Michiels, Stefan, Rothé, Françoise, Salgado, Roberto, Duvillier, Hugues, Ignatiadis, Michail, Desmedt, Christine, Bron, Dominique, Larsimont, Denis, Piccart, Martine, Sotiriou, Christos, Willard-Gallo, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Breast Neoplasms - immunology Breast Neoplasms - mortality Breast Neoplasms - pathology Case-Control Studies Cytokines - genetics Cytokines - metabolism Female Gene Expression Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Oligonucleotide Array Sequence Analysis Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transcriptome
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