Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice
Objective: To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice. Materials and Methods: Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21 st day, the eff...
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| Veröffentlicht in: | Indian journal of pharmacology 2013-05, Vol.45 (3), p.244-247 |
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| creator | Karve, Ashwini Jagtiani, Sagar Chitnis, Kunal |
| description | Objective: To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.
Materials and Methods: Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21 st day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
Results: Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
Conclusion: The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity. |
| doi_str_mv | 10.4103/0253-7613.111922 |
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Materials and Methods: Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21 st day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
Results: Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
Conclusion: The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.111922</identifier><identifier>PMID: 23833366</identifier><language>eng</language><publisher>India: Medknow Publications</publisher><subject>Allopurinol ; Allopurinol - administration & dosage ; Animals ; Antidepressants ; Antidepressive Agents - administration & dosage ; Behavior, Animal - drug effects ; Care and treatment ; Comparative analysis ; Depression - drug therapy ; Depression - physiopathology ; Depression - psychology ; Depression, Mental ; Disease Models, Animal ; Dosage and administration ; Drug Combinations ; Drug therapy ; Febuxostat ; Male ; Mental depression ; Mice ; Motor Activity - drug effects ; Pharmacology ; Rodents ; Swimming ; Thiazoles - administration & dosage</subject><ispartof>Indian journal of pharmacology, 2013-05, Vol.45 (3), p.244-247</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jun 2013</rights><rights>Copyright: © Indian Journal of Pharmacology 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588i-89c8dfba690f0027dd54135cacbe240a1e0f808f9b372bb26893d0a0e9b84fac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696294/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23833366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karve, Ashwini</creatorcontrib><creatorcontrib>Jagtiani, Sagar</creatorcontrib><creatorcontrib>Chitnis, Kunal</creatorcontrib><title>Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>Objective: To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.
Materials and Methods: Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21 st day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
Results: Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
Conclusion: The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.</description><subject>Allopurinol</subject><subject>Allopurinol - administration & dosage</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - administration & dosage</subject><subject>Behavior, Animal - drug effects</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Depression - psychology</subject><subject>Depression, Mental</subject><subject>Disease Models, Animal</subject><subject>Dosage and administration</subject><subject>Drug Combinations</subject><subject>Drug therapy</subject><subject>Febuxostat</subject><subject>Male</subject><subject>Mental depression</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Pharmacology</subject><subject>Rodents</subject><subject>Swimming</subject><subject>Thiazoles - administration & dosage</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1vEzEQhlcIRNPCnRNaifMGf63XviCVqhSkSlzghmR5vePUrWMHezeBf49XaUMjRT7463lfj2emqt5htGQY0Y-ItLTpOKZLjLEk5EW1wFKKhnYtflktDtdn1XnO96jsmeSvqzNCBaWU80X163qr_aRHF0MdbQ3WghnnlfY-bqbkQvS1DkNtoZ_-xDzqsXah7uFOb11M2tfrOICfFQNsEuQ8OxVi7Qy8qV5Z7TO8fZwvqp9frn9cfW1uv998u7q8bUwrhGuENGKwveYS2RJjNwwtw7Q12vRAGNIYkBVIWNnTjvQ94ULSAWkEshfMakMvqk97383Ur2EwEMYSmdokt9bpr4raqeOb4O7UKm4V5ZITyYrBh0eDFH9PkEd1H6cUSswKU85aijhq_1Mr7UG5YGMxM2uXjbqkFAtGuq4rVHOCWkGA8nIMYF05PuKXJ_gyBig5PClAe4FJMecE9vBRjNTcFmquu5rrrvZtUSTvnyfoIHjqgwJ83gO76EdI-cFPO0iqsA8h7o6Mm2fGijCmnjqI_gOirseW</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Karve, Ashwini</creator><creator>Jagtiani, Sagar</creator><creator>Chitnis, Kunal</creator><general>Medknow Publications</general><general>Medknow Publications and Media Pvt. 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Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice</title><author>Karve, Ashwini ; Jagtiani, Sagar ; Chitnis, Kunal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588i-89c8dfba690f0027dd54135cacbe240a1e0f808f9b372bb26893d0a0e9b84fac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Allopurinol</topic><topic>Allopurinol - administration & dosage</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - administration & dosage</topic><topic>Behavior, Animal - drug effects</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Depression - drug therapy</topic><topic>Depression - physiopathology</topic><topic>Depression - psychology</topic><topic>Depression, Mental</topic><topic>Disease Models, Animal</topic><topic>Dosage and administration</topic><topic>Drug Combinations</topic><topic>Drug therapy</topic><topic>Febuxostat</topic><topic>Male</topic><topic>Mental depression</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Pharmacology</topic><topic>Rodents</topic><topic>Swimming</topic><topic>Thiazoles - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karve, Ashwini</creatorcontrib><creatorcontrib>Jagtiani, Sagar</creatorcontrib><creatorcontrib>Chitnis, Kunal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karve, Ashwini</au><au>Jagtiani, Sagar</au><au>Chitnis, Kunal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice</atitle><jtitle>Indian journal of pharmacology</jtitle><addtitle>Indian J Pharmacol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>45</volume><issue>3</issue><spage>244</spage><epage>247</epage><pages>244-247</pages><issn>0253-7613</issn><eissn>1998-3751</eissn><abstract>Objective: To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.
Materials and Methods: Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21 st day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
Results: Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
Conclusion: The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.</abstract><cop>India</cop><pub>Medknow Publications</pub><pmid>23833366</pmid><doi>10.4103/0253-7613.111922</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Allopurinol Allopurinol - administration & dosage Animals Antidepressants Antidepressive Agents - administration & dosage Behavior, Animal - drug effects Care and treatment Comparative analysis Depression - drug therapy Depression - physiopathology Depression - psychology Depression, Mental Disease Models, Animal Dosage and administration Drug Combinations Drug therapy Febuxostat Male Mental depression Mice Motor Activity - drug effects Pharmacology Rodents Swimming Thiazoles - administration & dosage |
| title | Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice |
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