The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

Expression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration. This work explores the role of cleavage and polyadenylation specificity...

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Veröffentlicht in:	Retrovirology 2013-04, Vol.10 (1), p.46-46, Article 46
Hauptverfasser:	Fricke, Thomas, Valle-Casuso, Jose Carlos, White, Tommy E, Brandariz-Nuñez, Alberto, Bosche, William J, Reszka, Natalia, Gorelick, Robert, Diaz-Griffero, Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis beta Karyopherins - metabolism Cancer Cell Line Cells Experiments Genetic aspects HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus 1 Humans Infections Medical research Medicine, Experimental mRNA Cleavage and Polyadenylation Factors - metabolism Proteins Reverse Transcription RNA splicing Virus Integration
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