Intrinsic hyporesponsiveness of invariant natural killer T cells precedes the onset of lupus

Summary Patients with systemic lupus erythematosus (SLE) display reduced numbers and functions of invariant natural killer T (iNK T) cells, which are restored upon treatment with corticosteroids and rituximab. It is unclear whether the iNK T cell insufficiency is a consequence of disease or is a pri...

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Veröffentlicht in:	Clinical and experimental immunology 2013-07, Vol.173 (1), p.18-27
Hauptverfasser:	Yang, J.‐Q., Kim, P. J., Halder, R. C., Singh, R. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1 - immunology autoimmunity Cells, Cultured - immunology Cells, Cultured - secretion Crosses, Genetic Disease Models, Animal Female Galactosylceramides - immunology Humans Lupus Erythematosus, Systemic - etiology Lupus Erythematosus, Systemic - immunology Lymphocyte Activation Lymphocyte Cooperation Lymphocyte Count Lymphokines - secretion Mice Mice, Inbred BALB C Mice, Inbred NZB Natural Killer T-Cells - immunology Natural Killer T-Cells - secretion Prodromal Symptoms rodent systemic lupus erythematosus T cells Translational Studies
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