Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

Reactive oxygen species (ROS) play complex roles in aging, having both damaging effects and signaling functions. Transiently elevating mitochondrial stress, including mitochondrial ROS (mtROS), elicits beneficial responses that extend lifespan. However, these adaptive, longevity-signaling pathways r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2013-06, Vol.17 (6), p.954-964
Hauptverfasser:	Schroeder, Elizabeth A., Raimundo, Nuno, Shadel, Gerald S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Checkpoint Kinase 2 - genetics Checkpoint Kinase 2 - metabolism DNA Damage DNA Repair - genetics Epigenomics Gene Silencing Histone Demethylases - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Longevity - genetics Longevity - physiology Mitochondria - genetics Mitochondria - metabolism Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Reactive Oxygen Species - metabolism Repressor Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!