The X-Linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain

Intellectual disability is a prevalent disorder that remains incurable. Mutations of the X-linked protein PHF6 cause the intellectual disability disorder Börjeson-Forssman-Lehmann syndrome (BFLS). However, the biological role of PHF6 relevant to BFLS pathogenesis has remained unknown. We report that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2013-06, Vol.78 (6), p.986-993
Hauptverfasser:	Zhang, Chi, Mejia, Luis A., Huang, Ju, Valnegri, Pamela, Bennett, Eric J., Anckar, Julius, Jahani-Asl, Arezu, Gallardo, Gilbert, Ikeuchi, Yoshiho, Yamada, Tomoko, Rudnicki, Michael, Harper, J. Wade, Bonni, Azad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Brain - cytology Brain - physiology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Movement - physiology Female Gene Knockdown Techniques - methods Genes, X-Linked - genetics Genotype & phenotype Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Intellectual Disability - genetics Mice Migration Morphology Mutation Neurons Neurons - physiology Pathogenesis Plasmids Pregnancy Protein Binding - physiology Proteins Rats Software
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!