β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma

Background: The use of β -blockers for the management of hypertension has been recently associated with significant clinical benefits in cancer patients. Herein, we investigated whether β -blockers could be used in combination with chemotherapy for the treatment of neuroblastoma. Methods: Seven β -b...

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Veröffentlicht in:	British journal of cancer 2013-06, Vol.108 (12), p.2485-2494
Hauptverfasser:	Pasquier, E, Street, J, Pouchy, C, Carre, M, Gifford, A J, Murray, J, Norris, M D, Trahair, T, Andre, N, Kavallaris, M
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1922 692/700/565/1436/1437 Abdominal Neoplasms - blood supply Abdominal Neoplasms - drug therapy Abdominal Neoplasms - pathology Adrenergic beta-Antagonists - therapeutic use Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Drug Resistance Drug Synergism Epidemiology Humans Medical sciences Mice Mice, Transgenic Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neovascularization, Pathologic - drug therapy Neuroblastoma - blood supply Neuroblastoma - drug therapy Neuroblastoma - pathology Neurology Oncology Translational Therapeutics Tumors Tumors of the nervous system. Phacomatoses
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