Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin‐releasing hormone (GnRH) neurons
We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin‐releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E‐mediated n...
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| Veröffentlicht in: | Developmental dynamics 2010-06, Vol.239 (6), p.1723-1738 |
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| creator | Rawson, N.E. Lischka, F. W. Yee, K.K. Peters, A.Z. Tucker, E.S. Meechan, D.W. Zirlinger, M. Maynard, T.M. Burd, G.B. Dulac, C. Pevny, L. LaMantia, A.‐S. |
| description | We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin‐releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E‐mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE‐specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons. Developmental Dynamics 239:1723–1738, 2010. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.22315 |
| format | Article |
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W. ; Yee, K.K. ; Peters, A.Z. ; Tucker, E.S. ; Meechan, D.W. ; Zirlinger, M. ; Maynard, T.M. ; Burd, G.B. ; Dulac, C. ; Pevny, L. ; LaMantia, A.‐S.</creator><creatorcontrib>Rawson, N.E. ; Lischka, F. W. ; Yee, K.K. ; Peters, A.Z. ; Tucker, E.S. ; Meechan, D.W. ; Zirlinger, M. ; Maynard, T.M. ; Burd, G.B. ; Dulac, C. ; Pevny, L. ; LaMantia, A.‐S.</creatorcontrib><description>We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin‐releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E‐mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE‐specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons. 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W.</creatorcontrib><creatorcontrib>Yee, K.K.</creatorcontrib><creatorcontrib>Peters, A.Z.</creatorcontrib><creatorcontrib>Tucker, E.S.</creatorcontrib><creatorcontrib>Meechan, D.W.</creatorcontrib><creatorcontrib>Zirlinger, M.</creatorcontrib><creatorcontrib>Maynard, T.M.</creatorcontrib><creatorcontrib>Burd, G.B.</creatorcontrib><creatorcontrib>Dulac, C.</creatorcontrib><creatorcontrib>Pevny, L.</creatorcontrib><creatorcontrib>LaMantia, A.‐S.</creatorcontrib><title>Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin‐releasing hormone (GnRH) neurons</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin‐releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E‐mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE‐specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons. Developmental Dynamics 239:1723–1738, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Cell Differentiation - physiology</subject><subject>Embryo, Mammalian</subject><subject>Epithelium - metabolism</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>induction</subject><subject>limb bud</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Morphogenesis</subject><subject>neurogenesis</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>olfactory</subject><subject>Olfactory Mucosa - cytology</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory Receptor Neurons - metabolism</subject><subject>Signal Transduction</subject><subject>Transcription Factors - metabolism</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhq0KREthwwMg7yhV09px4iQbpKqlF6kSEpdKrCzHOZ4xcuxgJ4OygzfoM_ZJ8HTaim5Y-Vj-_Pkc_wi9oeSQEpIfdatuPsxzRssttENJU2WEVtWzdV3WWc3qehu9jPEHIaTmBX2BtnNSEsZ4vYP-fBlAGW0U7iGCU8u5l_YIBjMuwRppsXHdpEbjHfYae6ulGn2YcQAFQ6oO8Mr3ELyTUdoDLF2HF2nT-TH4wbjb3zcBLMho3AIvfei9A7x37j5fvMcOpnQvvkLPtbQRXt-vu-jb2cevJxfZ1afzy5Pjq0wVtCkzDpprVbGcp8bbtoGCFhoUbWue5mJS0aqWVV4QVpCuSTO3XFdlKRkpddGwlu2iDxvvMLU9dArcGKQVQzC9DLPw0oinJ84sxcKvBONNTmiRBO_uBcH_nCCOojdRgbXSgZ-iqBijhKevTeT-hlTBxxhAP75CiVhHJtaRibvIEvz2374e0YeMEkA3wC9jYf6PSpxen37fSP8CNoql3w</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Rawson, N.E.</creator><creator>Lischka, F. 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W. ; Yee, K.K. ; Peters, A.Z. ; Tucker, E.S. ; Meechan, D.W. ; Zirlinger, M. ; Maynard, T.M. ; Burd, G.B. ; Dulac, C. ; Pevny, L. ; LaMantia, A.‐S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-6ef6fc7326336bb9e414fec1b860003ac178a7240340d9388b6f755a305f493b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cell Differentiation - physiology</topic><topic>Embryo, Mammalian</topic><topic>Epithelium - metabolism</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>induction</topic><topic>limb bud</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Morphogenesis</topic><topic>neurogenesis</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>olfactory</topic><topic>Olfactory Mucosa - cytology</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory Receptor Neurons - metabolism</topic><topic>Signal Transduction</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rawson, N.E.</creatorcontrib><creatorcontrib>Lischka, F. W.</creatorcontrib><creatorcontrib>Yee, K.K.</creatorcontrib><creatorcontrib>Peters, A.Z.</creatorcontrib><creatorcontrib>Tucker, E.S.</creatorcontrib><creatorcontrib>Meechan, D.W.</creatorcontrib><creatorcontrib>Zirlinger, M.</creatorcontrib><creatorcontrib>Maynard, T.M.</creatorcontrib><creatorcontrib>Burd, G.B.</creatorcontrib><creatorcontrib>Dulac, C.</creatorcontrib><creatorcontrib>Pevny, L.</creatorcontrib><creatorcontrib>LaMantia, A.‐S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rawson, N.E.</au><au>Lischka, F. W.</au><au>Yee, K.K.</au><au>Peters, A.Z.</au><au>Tucker, E.S.</au><au>Meechan, D.W.</au><au>Zirlinger, M.</au><au>Maynard, T.M.</au><au>Burd, G.B.</au><au>Dulac, C.</au><au>Pevny, L.</au><au>LaMantia, A.‐S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin‐releasing hormone (GnRH) neurons</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2010-06</date><risdate>2010</risdate><volume>239</volume><issue>6</issue><spage>1723</spage><epage>1738</epage><pages>1723-1738</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin‐releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E‐mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE‐specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons. Developmental Dynamics 239:1723–1738, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley‐Liss, Inc</pub><pmid>20503368</pmid><doi>10.1002/dvdy.22315</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Cell Differentiation - physiology Embryo, Mammalian Epithelium - metabolism Gonadotropin-Releasing Hormone - metabolism induction limb bud Mice Mice, Transgenic Morphogenesis neurogenesis Neurons - cytology Neurons - metabolism olfactory Olfactory Mucosa - cytology Olfactory Mucosa - metabolism Olfactory Receptor Neurons - metabolism Signal Transduction Transcription Factors - metabolism |
| title | Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin‐releasing hormone (GnRH) neurons |
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