Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia
Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes to the pathogenesis of anemia in patients with cancer and may lead to several symptoms such as impaired physical function, weakness and fatigue....
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| Veröffentlicht in: | Annals of oncology 2013-07, Vol.24 (7), p.1886-1892 |
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| creator | Ludwig, H. Müldür, E. Endler, G. Hübl, W. |
| description | Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes to the pathogenesis of anemia in patients with cancer and may lead to several symptoms such as impaired physical function, weakness and fatigue.
Parameters of iron status and clinical parameters were evaluated in 1528 patients with cancer who presented consecutively within a four-month period at our center. One thousand fifty-three patients had solid tumors and 475 hematological malignancies.
ID [transferrin saturation (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests available and 500 (33.0%) were anemic. ID rates were highest in pancreatic (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) and ECOG performance status (P = 0.005).
ID was frequently noted in cancer and was associated with advanced disease, close proximity to cancer therapy, and poor performance status in patients with solid tumors. |
| doi_str_mv | 10.1093/annonc/mdt118 |
| format | Article |
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Parameters of iron status and clinical parameters were evaluated in 1528 patients with cancer who presented consecutively within a four-month period at our center. One thousand fifty-three patients had solid tumors and 475 hematological malignancies.
ID [transferrin saturation (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests available and 500 (33.0%) were anemic. ID rates were highest in pancreatic (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) and ECOG performance status (P = 0.005).
ID was frequently noted in cancer and was associated with advanced disease, close proximity to cancer therapy, and poor performance status in patients with solid tumors.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdt118</identifier><identifier>PMID: 23567147</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>absolute iron deficiency ; Adult ; Aged ; Aged, 80 and over ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Iron-Deficiency - etiology ; Anemias. Hemoglobinopathies ; Antineoplastic agents ; Biological and medical sciences ; cancer-related anemia ; chemotherapy-induced anemia ; Diseases of red blood cells ; Female ; functional iron deficiency ; Hematologic and hematopoietic diseases ; Humans ; iron deficiency ; iron deficiency anemia ; Male ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasms - complications ; Neoplasms - epidemiology ; Neoplasms - therapy ; Original ; Other metabolic disorders ; Pharmacology. Drug treatments ; Prevalence ; Severity of Illness Index ; Tumors ; Young Adult</subject><ispartof>Annals of oncology, 2013-07, Vol.24 (7), p.1886-1892</ispartof><rights>2013 THE AUTHORS</rights><rights>2014 INIST-CNRS</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-716e1fa3b373c182f94df830c97863bba3a8c01fb75219f9a29425391978b3e83</citedby><cites>FETCH-LOGICAL-c465t-716e1fa3b373c182f94df830c97863bba3a8c01fb75219f9a29425391978b3e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27480877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23567147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ludwig, H.</creatorcontrib><creatorcontrib>Müldür, E.</creatorcontrib><creatorcontrib>Endler, G.</creatorcontrib><creatorcontrib>Hübl, W.</creatorcontrib><title>Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes to the pathogenesis of anemia in patients with cancer and may lead to several symptoms such as impaired physical function, weakness and fatigue.
Parameters of iron status and clinical parameters were evaluated in 1528 patients with cancer who presented consecutively within a four-month period at our center. One thousand fifty-three patients had solid tumors and 475 hematological malignancies.
ID [transferrin saturation (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests available and 500 (33.0%) were anemic. ID rates were highest in pancreatic (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) and ECOG performance status (P = 0.005).
ID was frequently noted in cancer and was associated with advanced disease, close proximity to cancer therapy, and poor performance status in patients with solid tumors.</description><subject>absolute iron deficiency</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Iron-Deficiency - etiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>cancer-related anemia</subject><subject>chemotherapy-induced anemia</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>functional iron deficiency</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>iron deficiency</subject><subject>iron deficiency anemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - therapy</subject><subject>Original</subject><subject>Other metabolic disorders</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Severity of Illness Index</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1v1DAQxS1ERZfCkSvyBYkDae04ie0LEqr4kirBAc7WxBlToyRebGdRj_zneDfb0h44jez5-XnmPUJecHbOmRYXMM9hthfTkDlXj8iGt52uFGv4Y7JhuhaVbEVzSp6m9JMx1ulaPyGntWg7yRu5IX--RtzBiLNFGhz1Mcx0QOetL1c3FGwMKdHBO4cR50zzMoWYKMwD9bnUlIL1kH159tvna7oNIdItRhfiBHvRlCEv6U2RSAjp9nwQgBknD8_IiYMx4fNjPSPfP7z_dvmpuvry8fPlu6vKNl2bK8k75A5EL6SwXNVON4NTglktVSf6HgQoy7jrZVtz7TTUuqlboXnp9wKVOCNvV93t0k842LJNhNFso58g3pgA3jzszP7a_Ag7IzrNNNsLvD4KxPBrwZTN5JPFcSx7hCUZLmTNFOtEU9BqRQ_2RXR333Bm9rGZNTazxlb4l_dnu6NvcyrAqyMAycLoYvHWp3-cbBRTcs_JlcPi5M5jNOmQJA4-os1mCP4_I_wFhnm57w</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Ludwig, H.</creator><creator>Müldür, E.</creator><creator>Endler, G.</creator><creator>Hübl, W.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130701</creationdate><title>Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia</title><author>Ludwig, H. ; Müldür, E. ; Endler, G. ; Hübl, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-716e1fa3b373c182f94df830c97863bba3a8c01fb75219f9a29425391978b3e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>absolute iron deficiency</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Iron-Deficiency - etiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>cancer-related anemia</topic><topic>chemotherapy-induced anemia</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>functional iron deficiency</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>iron deficiency</topic><topic>iron deficiency anemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - therapy</topic><topic>Original</topic><topic>Other metabolic disorders</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Severity of Illness Index</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ludwig, H.</creatorcontrib><creatorcontrib>Müldür, E.</creatorcontrib><creatorcontrib>Endler, G.</creatorcontrib><creatorcontrib>Hübl, W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ludwig, H.</au><au>Müldür, E.</au><au>Endler, G.</au><au>Hübl, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>24</volume><issue>7</issue><spage>1886</spage><epage>1892</epage><pages>1886-1892</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes to the pathogenesis of anemia in patients with cancer and may lead to several symptoms such as impaired physical function, weakness and fatigue.
Parameters of iron status and clinical parameters were evaluated in 1528 patients with cancer who presented consecutively within a four-month period at our center. One thousand fifty-three patients had solid tumors and 475 hematological malignancies.
ID [transferrin saturation (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests available and 500 (33.0%) were anemic. ID rates were highest in pancreatic (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) and ECOG performance status (P = 0.005).
ID was frequently noted in cancer and was associated with advanced disease, close proximity to cancer therapy, and poor performance status in patients with solid tumors.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>23567147</pmid><doi>10.1093/annonc/mdt118</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | absolute iron deficiency Adult Aged Aged, 80 and over Anemia, Iron-Deficiency - epidemiology Anemia, Iron-Deficiency - etiology Anemias. Hemoglobinopathies Antineoplastic agents Biological and medical sciences cancer-related anemia chemotherapy-induced anemia Diseases of red blood cells Female functional iron deficiency Hematologic and hematopoietic diseases Humans iron deficiency iron deficiency anemia Male Medical sciences Metabolic diseases Metals (hemochromatosis...) Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - complications Neoplasms - epidemiology Neoplasms - therapy Original Other metabolic disorders Pharmacology. Drug treatments Prevalence Severity of Illness Index Tumors Young Adult |
| title | Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia |
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